Is Fecal Leukocyte Test a good predictor of Clostridium difficile associated diarrhea?

Fecal leukocyte test (FLT) is widely used to screen for invasive diarrheas including C. difficile associated diarrhea (CDAD), which account for more than 25 % of all antibiotic associated diarrhea. 263 stool samples from patients with suspected CDAD were studied simultaneously for fecal leukocyte te...

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Bibliographic Details
Published in:Annals of clinical microbiology and antimicrobials 2006-04, Vol.5 (1), p.9-9
Main Authors: Reddymasu, Savio, Sheth, Ankur, Banks, Daniel E
Format: Article
Language:English
Subjects:
Bacterial Proteins - analysis
Bacterial Toxins - analysis
Clostridium difficile
Diarrhea - diagnosis
Enterocolitis, Pseudomembranous - diagnosis
Enterotoxins - analysis
Feces - cytology
Humans
Leukocytes
Retrospective Studies
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Summary:Fecal leukocyte test (FLT) is widely used to screen for invasive diarrheas including C. difficile associated diarrhea (CDAD), which account for more than 25 % of all antibiotic associated diarrhea. 263 stool samples from patients with suspected CDAD were studied simultaneously for fecal leukocyte test (FLT) and Clostridium difficile toxin assay (CDTA). FLT was performed by the Giemsa technique and CDTA was performed by enzyme immuno assay (EIA). Sensitivity, specificity, positive predictive value and negative predictive value of FLT as compared to CDTA were 30%, 74.9%, 13.2% and 89.3% respectively. Considering the poor sensitivity of FLT, and the comparable cost and time of obtaining a CDTA at our institution, we conclude that FLT is not a good screening test for CDAD. Possible reasons for FLT being a poor predictor of CDTA are discussed.
ISSN:1476-0711
1476-0711
DOI:10.1186/1476-0711-5-9