Gene Expression and Prognostic Value of NADPH Oxidase Enzymes in Breast Cancer

NADPH oxidase enzymes (NOX) are involved in all stages of carcinogenesis, but their expression levels and prognostic value in breast cancer (BC) remain unclear. Thus, we aimed to assess the expression and prognostic value of NOX enzymes in BC samples using online databases. For this, mRNA expression...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-03, Vol.25 (6), p.3464
Main Authors: de Vasconcelos E Souza, Andressa, de Faria, Caroline Coelho, Pereira, Leonardo Matta, Ferreira, Andrea Claudia Freitas, Torres, Pedro Henrique Monteiro, Fortunato, Rodrigo Soares
Format: Article
Language:English
Subjects:
Binding sites
Breast cancer
Breast Neoplasms - genetics
Cancer
Communication
Development and progression
Dual Oxidases - genetics
Enzymes
Estrogens
Female
Gene Expression
Genetic aspects
Humans
Medical prognosis
Metastasis
NADPH Oxidase 1 - genetics
NADPH Oxidase 4 - genetics
NADPH oxidases
NADPH Oxidases - genetics
NADPH Oxidases - metabolism
Online databases
Oxidases
Physiology
Prognosis
reactive oxygen species
Reactive Oxygen Species - metabolism
RNA
RNA, Messenger - genetics
Survival analysis
tumor aggressiveness
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Summary:NADPH oxidase enzymes (NOX) are involved in all stages of carcinogenesis, but their expression levels and prognostic value in breast cancer (BC) remain unclear. Thus, we aimed to assess the expression and prognostic value of NOX enzymes in BC samples using online databases. For this, mRNA expression from 290 normal breast tissue samples and 1904 BC samples obtained from studies on cBioPortal, Kaplan-Meier Plotter, and The Human Protein Atlas were analyzed. We found higher levels of NOX2, NOX4, and Dual oxidase 1 (DUOX1) in normal breast tissue. NOX1, NOX2, and NOX4 exhibited higher expression in BC, except for the basal subtype, where NOX4 expression was lower. DUOX1 mRNA levels were lower in all BC subtypes. NOX2, NOX4, and NOX5 mRNA levels increased with tumor progression stages, while NOX1 and DUOX1 expression decreased in more advanced stages. Moreover, patients with low expression of NOX1, NOX4, and DUOX1 had lower survival rates than those with high expression of these enzymes. In conclusion, our data suggest an overexpression of NOX enzymes in breast cancer, with certain isoforms showing a positive correlation with tumor progression.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25063464