Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity

Mechanisms underlying the central regulation of food intake and fat accumulation are not fully understood. We found that neurosecretory protein GL (NPGL), a newly-identified neuropeptide, increased food intake and white adipose tissue (WAT) in rats. NPGL-precursor gene overexpression in the hypothal...

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Bibliographic Details
Published in:eLife 2017-08, Vol.6
Main Authors: Iwakoshi-Ukena, Eiko, Shikano, Kenshiro, Kondo, Kunihiro, Taniuchi, Shusuke, Furumitsu, Megumi, Ochi, Yuta, Sasaki, Tsutomu, Okamoto, Shiki, Bentley, George E, Kriegsfeld, Lance J, Minokoshi, Yasuhiko, Ukena, Kazuyoshi
Format: Article
Language:English
Subjects:
Adipose tissue
Amino acids
Animals
Body mass
Chemical bonds
Diabetes
Eating
Endocrinology
Energy
fat accumulation
Fatty acids
Food
Food intake
Gene expression
Gene Expression Profiling
Health aspects
Homeostasis
Hypothalamus
Hypothalamus - metabolism
Insulin
Insulin - metabolism
Intracerebroventricular administration
Lipogenesis
Metabolism
Nerve tissue proteins
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - metabolism
neuropeptide
Neuropeptides
Neuroscience
Neurosciences
Obesity
Obesity - physiopathology
Peptides
Physiological aspects
Physiology
Poultry
Proteins
Rats
Rodents
Variance analysis
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Summary:Mechanisms underlying the central regulation of food intake and fat accumulation are not fully understood. We found that neurosecretory protein GL (NPGL), a newly-identified neuropeptide, increased food intake and white adipose tissue (WAT) in rats. NPGL-precursor gene overexpression in the hypothalamus caused increases in food intake, WAT, body mass, and circulating insulin when fed a high calorie diet. Intracerebroventricular administration of NPGL induced de novo lipogenesis in WAT, increased insulin, and it selectively induced carbohydrate intake. Neutralizing antibody administration decreased the size of lipid droplets in WAT. mRNA expression was upregulated by fasting and low insulin levels. Additionally, NPGL-producing cells were responsive to insulin. These results point to NPGL as a novel neuronal regulator that drives food intake and fat deposition through de novo lipogenesis and acts to maintain steady-state fat level in concert with insulin. Dysregulation of NPGL may be a root cause of obesity.
ISSN:2050-084X
2050-084X
DOI:10.7554/elife.28527