Clinical strategy study on prenatal screening and diagnostic model for Down syndrome

• Published in: Scientific reports 2024-09, Vol.14 (1), p.22269-11, Article 22269
• Main Authors: Luo, Wei, Liu, Sha, He, Bin, Han, Daiwen, Yuan, Lixing, Zhao, Kai, Tang, Jun, Pang, Ling, Zou, Fene, Liu, Jianlong, Liu, Hongqian, Bai, Ting, Jing, Xiaosha, Xia, Tianyu, Deng, Cechuan, Liu, Yunyun, Cheng, Jing, Wei, Xiang, Xing, Lingling, Luo, Yuan, Zhou, Quanfang, Zhu, Qian, Liu, Shanling
• Format: Article
• Language: English
• Subjects: 692/308/2056; 692/53/2423; 692/700/3934; Adult; Birth defects; China - epidemiology; Congenital defects; Cost analysis; Cost-Benefit Analysis; Down syndrome; Down Syndrome - diagnosis; Down's syndrome; Economics; Female; Health economics; Humanities and Social Sciences; Humans; multidisciplinary; Non-invasive prenatal screening; Noninvasive Prenatal Testing - methods; Pregnancy; Prenatal diagnosis; Prenatal Diagnosis - economics; Prenatal Diagnosis - methods; Science; Science (multidisciplinary); Serological screening; Serology
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-73183-4

Exploring efficient and easily implementable prenatal screening strategies aims at birth defect prevention and control. However, there have been limited economic evaluations of non-invasive prenatal screening (NIPS) strategies in China. Furthermore, these studies were predominantly confined to local or geographically proximate provinces and lacked universality and representativeness. This study assesses the health economics of current prenatal screening strategies and NIPS as first-line screening programs, analyzing their efficacy to determine an optimal strategy. From the perspective of health economics, cost-effectiveness, cost-benefit, and single-factor sensitivity were conducted for five different screening strategies using a decision tree model. Among pregnant women aged