Clinical strategy study on prenatal screening and diagnostic model for Down syndrome

Exploring efficient and easily implementable prenatal screening strategies aims at birth defect prevention and control. However, there have been limited economic evaluations of non-invasive prenatal screening (NIPS) strategies in China. Furthermore, these studies were predominantly confined to local...

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Published in:Scientific reports 2024-09, Vol.14 (1), p.22269-11, Article 22269
Main Authors: Luo, Wei, Liu, Sha, He, Bin, Han, Daiwen, Yuan, Lixing, Zhao, Kai, Tang, Jun, Pang, Ling, Zou, Fene, Liu, Jianlong, Liu, Hongqian, Bai, Ting, Jing, Xiaosha, Xia, Tianyu, Deng, Cechuan, Liu, Yunyun, Cheng, Jing, Wei, Xiang, Xing, Lingling, Luo, Yuan, Zhou, Quanfang, Zhu, Qian, Liu, Shanling
Format: Article
Language:English
Subjects:
692/308/2056
692/53/2423
692/700/3934
Adult
Birth defects
China - epidemiology
Congenital defects
Cost analysis
Cost-Benefit Analysis
Down syndrome
Down Syndrome - diagnosis
Down's syndrome
Economics
Female
Health economics
Humanities and Social Sciences
Humans
multidisciplinary
Non-invasive prenatal screening
Noninvasive Prenatal Testing - methods
Pregnancy
Prenatal diagnosis
Prenatal Diagnosis - economics
Prenatal Diagnosis - methods
Science
Science (multidisciplinary)
Serological screening
Serology
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container_title Scientific reports
container_volume 14
creator Luo, Wei
Liu, Sha
He, Bin
Han, Daiwen
Yuan, Lixing
Zhao, Kai
Tang, Jun
Pang, Ling
Zou, Fene
Liu, Jianlong
Liu, Hongqian
Bai, Ting
Jing, Xiaosha
Xia, Tianyu
Deng, Cechuan
Liu, Yunyun
Cheng, Jing
Wei, Xiang
Xing, Lingling
Luo, Yuan
Zhou, Quanfang
Zhu, Qian
Liu, Shanling
description Exploring efficient and easily implementable prenatal screening strategies aims at birth defect prevention and control. However, there have been limited economic evaluations of non-invasive prenatal screening (NIPS) strategies in China. Furthermore, these studies were predominantly confined to local or geographically proximate provinces and lacked universality and representativeness. This study assesses the health economics of current prenatal screening strategies and NIPS as first-line screening programs, analyzing their efficacy to determine an optimal strategy. From the perspective of health economics, cost-effectiveness, cost-benefit, and single-factor sensitivity were conducted for five different screening strategies using a decision tree model. Among pregnant women aged 
doi_str_mv 10.1038/s41598-024-73183-4
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subjects 692/308/2056
692/53/2423
692/700/3934
Adult
Birth defects
China - epidemiology
Congenital defects
Cost analysis
Cost-Benefit Analysis
Down syndrome
Down Syndrome - diagnosis
Down's syndrome
Economics
Female
Health economics
Humanities and Social Sciences
Humans
multidisciplinary
Non-invasive prenatal screening
Noninvasive Prenatal Testing - methods
Pregnancy
Prenatal diagnosis
Prenatal Diagnosis - economics
Prenatal Diagnosis - methods
Science
Science (multidisciplinary)
Serological screening
Serology
title Clinical strategy study on prenatal screening and diagnostic model for Down syndrome
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