Molecular imaging of tumor-associated macrophages in cancer immunotherapy

Tumor-associated macrophages (TAMs), the most abundant inflammatory cell group in the tumor microenvironment, play an essential role in tumor immune regulation. The infiltration degree of TAMs in the tumor microenvironment is closely related to tumor growth and metastasis, and TAMs have become a pro...

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Bibliographic Details
Published in:Therapeutic Advances in Medical Oncology 2022-02, Vol.14, p.17588359221076194-17588359221076194
Main Authors: Li, Xiaoying, Wang, Ruike, Zhang, Yangnan, Han, Shuangze, Gan, Yu, Liang, Qi, Ma, Xiaoqian, Rong, Pengfei, Wang, Wei, Li, Wei
Format: Article
Language:English
Subjects:
Cancer immunotherapy
Immunoregulation
Immunotherapy
Inflammation
Macrophages
Metastases
Nuclear medicine
Review
Tumor microenvironment
Tumors
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Summary:Tumor-associated macrophages (TAMs), the most abundant inflammatory cell group in the tumor microenvironment, play an essential role in tumor immune regulation. The infiltration degree of TAMs in the tumor microenvironment is closely related to tumor growth and metastasis, and TAMs have become a promising target in tumor immunotherapy. Molecular imaging is a new interdisciplinary subject that combines medical imaging technology with molecular biology, nuclear medicine, radiation medicine, and computer science. The latest progress in molecular imaging allows the biological processes of cells to be visualized in vivo, which makes it possible to better understand the density and distribution of macrophages in the tumor microenvironment. This review mainly discusses the application of targeting TAM in tumor immunotherapy and the imaging characteristics and progress of targeting TAM molecular probes using various imaging techniques.
ISSN:1758-8359
1758-8340
1758-8359
DOI:10.1177/17588359221076194