New chroman-4-one/thiochroman-4-one derivatives as potential anticancer agents

The synthesis of 3-[3/4-(2-aryl-2-oxoethoxy)arylidene]chroman/thiochroman-4-one derivatives (1–34) and evaluation of their anticancer activities were aimed in this work. Final compounds were obtained in multistep synthesis reactions using phenol/thiophenol derivatives as starting materials. For anti...

Full description

Saved in:
Bibliographic Details
Published in:Saudi pharmaceutical journal 2017-11, Vol.25 (7), p.1063-1072
Main Authors: Demirayak, Seref, Yurttas, Leyla, Gundogdu-Karaburun, Nalan, Karaburun, Ahmet Cagri, Kayagil, Ismail
Format: Article
Language:English
Subjects:
Anticancer activity
Benzopyranone
Benzothiopyranone
Chromanone
Flavone
Original
Thiochromanone
α,β-Unsaturated carbonyl
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The synthesis of 3-[3/4-(2-aryl-2-oxoethoxy)arylidene]chroman/thiochroman-4-one derivatives (1–34) and evaluation of their anticancer activities were aimed in this work. Final compounds were obtained in multistep synthesis reactions using phenol/thiophenol derivatives as starting materials. For anticancer activity evaluation, all compounds were offered to National Cancer Institute (NCI), USA and selected ones were tested against sixty human tumor cell lines derived from nine neoplastic diseases. The activity results were evaluated according to the drug screening protocol of the institute. Compounds containing thiochromanone skeleton exhibited higher anticancer activity.
ISSN:1319-0164
2213-7475
DOI:10.1016/j.jsps.2017.04.040