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Effectiveness, reliability, and validity of new Japanese diagnostic criteria for obstetrical disseminated intravascular coagulation

Since July 2022, obstetrical disseminated intravascular coagulation (DIC) in Japan has been diagnosed based on the new criteria (tentative version), which assesses the main underlying disease, fibrinogen level, and fibrin/fibrinogen degradation products or D-dimer level. In June 2024, the tentative...

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Bibliographic Details
Published in:Scientific reports 2024-07, Vol.14 (1), p.17677-11, Article 17677
Main Authors: Morikawa, Mamoru, Takeda, Yoshiharu, Matsunaga, Shigetaka, Makino, Shintaro, Eto, Eriko, Serizawa, Mariko, Nii, Masafumi, Takeda, Jun, Masuyama, Hisashi, Itakura, Atsuo
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Language:English
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Summary:Since July 2022, obstetrical disseminated intravascular coagulation (DIC) in Japan has been diagnosed based on the new criteria (tentative version), which assesses the main underlying disease, fibrinogen level, and fibrin/fibrinogen degradation products or D-dimer level. In June 2024, the tentative version underwent minor revision and the final version was released. The previous Japanese criteria assessed underlying disease, clinical symptoms, and various laboratory findings. This study aimed to prove the effectiveness, reliability, and validity of the new criteria (final version). We analyzed 212 women with singleton pregnancies who delivered after 22 gestational weeks and experienced blood loss ≥ 1000 mL during vaginal delivery or ≥ 2000 mL during cesarean section. Those with missing laboratory findings before receiving blood transfusion at delivery were excluded. In the obstetrical DIC group, the frequency of fibrinogen levels
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-68298-7