Preventive Antibiotic Therapy in the Placement of Immediate Implants: A Systematic Review

Immediate implants present a high risk of early failure. To avoid this, preventive antibiotics (PAs) are prescribed; however, their inappropriate administration leads to antimicrobial resistance. The present study aims to clarify whether the prescription of PAs reduces the rate of early failure of i...

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Bibliographic Details
Published in:Antibiotics (Basel) 2021-12, Vol.11 (1), p.5
Main Authors: Salgado-Peralvo, Angel-Orión, Peña-Cardelles, Juan-Francisco, Kewalramani, Naresh, Mateos-Moreno, María-Victoria, Jiménez-Guerra, Álvaro, Velasco-Ortega, Eugenio, Uribarri, Andrea, Moreno-Muñoz, Jesús, Ortiz-García, Iván, Núñez-Márquez, Enrique, Monsalve-Guil, Loreto
Format: Article
Language:English
Subjects:
Allergies
Amoxicillin
antibiotic
antibiotic prophylaxis
Antibiotics
Antimicrobial resistance
Azithromycin
Bias
Clarithromycin
Clindamycin
Clinical trials
Criteria
dental implant complications
Dental implants
early failure
Failure rates
immediate implants
Implants
Infections
Medical Subject Headings-MeSH
Meta-analysis
Metronidazole
Penicillin
preventive antibiotics
Review
Systematic review
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Summary:Immediate implants present a high risk of early failure. To avoid this, preventive antibiotics (PAs) are prescribed; however, their inappropriate administration leads to antimicrobial resistance. The present study aims to clarify whether the prescription of PAs reduces the rate of early failure of immediate implants and to establish guidelines to avoid the overprescription of these drugs. An electronic search of the MEDLINE database (via PubMed), Web of Science, Scopus, LILACS and OpenGrey was carried out. The criteria described in the PRISMA statement were used. The search was temporarily restricted from 2010 to 2021. The risk of bias was analysed using the SIGN Methodological Assessment Checklist for Systematic Reviews and Meta-Analyses and the JBI Prevalence Critical Appraisal Tool. After searching, eight studies were included that met the established criteria. With the limitations of this study, it can be stated that antibiotic prescription in immediate implants reduces the early failure rate. Preoperative administration of 2-3 g amoxicillin one hour before surgery followed by 500 mg/8 h for five to seven days is recommended. It is considered prudent to avoid the use of clindamycin in favour of azithromycin, clarithromycin or metronidazole in penicillin allergy patients until further studies are conducted.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics11010005