Synthesis of triptorelin lactate catalyzed by lipase in organic media

Triptorelin lactate was successfully synthesized by porcine pancreatic lipase (PPL) in organic solvents. The effects of acyl donor, substrate ratio, organic solvent, temperature, and water activity were investigated. Under the optimum conditions, a yield of 30% for its ester could be achieved in the...

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Bibliographic Details
Published in:International journal of molecular sciences 2012-08, Vol.13 (8), p.9971-9979
Main Authors: Zhuang, Hong, Wang, Zhi, Wang, Jiaxin, Zhang, Hong, Xun, Erna, Chen, Ge, Yue, Hong, Tang, Ning, Wang, Lei
Format: Article
Language:English
Subjects:
Animals
Bacteria - enzymology
Catalysis
enzyme activity
Enzymes
Esterification
Hydrocarbons
Hydrogen-Ion Concentration
Kinetics
Lactates - chemistry
lipase
Lipase - metabolism
Organic Chemicals - chemistry
Peptides
Proteins
Solvents
Solvents - chemistry
Swine
Temperature
triptorelin lactate
Triptorelin Pamoate - analogs & derivatives
Triptorelin Pamoate - chemical synthesis
Triptorelin Pamoate - chemistry
Water - chemistry
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Summary:Triptorelin lactate was successfully synthesized by porcine pancreatic lipase (PPL) in organic solvents. The effects of acyl donor, substrate ratio, organic solvent, temperature, and water activity were investigated. Under the optimum conditions, a yield of 30% for its ester could be achieved in the reaction for about 48 h.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms13089971