Validation and Functional Relevance of the Short Form of the Perceived Deficits Questionnaire for Depression for Japanese Patients with Major Depressive Disorder

• Published in: Neuropsychiatric disease and treatment 2022-01, Vol.18, p.2507-2517
• Main Authors: Sumiyoshi, Tomiki, Uchida, Hiroyuki, Watanabe, Koichiro, Oosawa, Masato, Ren, Hongye, Moriguchi, Yoshiya, Fujikawa, Keita, Fernandez, Jovelle
• Format: Article
• Language: English
• Subjects: Antidepressants; Clinical trials; cognition; Cognition & reasoning; Cognition disorders; Cognitive ability; Complications and side effects; Diagnosis; Evaluation; functional impairment; Major depressive disorder; Memory; Mental depression; Mental disorders; Mental health surveys; Original Research; Patients; pdq-d-20; pdq-d-5; Productivity; Quality of life; Questionnaires; Surveys; Validity; Variables
• ISSN: 1176-6328; 1178-2021; 1178-2021
• DOI: 10.2147/NDT.S381647

To validate the five-item version of the Perceived Deficits Questionnaire for Depression (PDQ-D-5) for assessing subjective cognitive function in Japanese patients with major depressive disorder (MDD) using data from the PERFORM-J study. A total of 518 Japanese outpatients diagnosed with MDD were assessed on severity of depressive symptoms, cognitive function, social and work function, and quality of life (QoL) over 6 months following initiation of antidepressant therapy. This post hoc analysis evaluated the internal consistency and convergent validity of the PDQ-D-5 in relation to the original PDQ-D-20. Correlations of scores on these measures were examined at each time point and over time. The same set of analyses was explored between PDQ-D-5 and the Patient Health Questionnaire-nine-item (PHQ-9), Montgomery-Asberg Depression Rating Scale (MADRS), Digit Symbol Substitution Test (DSST), five-level version of EQ-5D (EQ-5D-5L), Sheehan Disability Scale (SDS), and Work Productivity and Activity Impairment (WPAI) questionnaire. PDQ-D-5 scores showed good internal consistency. Strong positive correlations were observed between PDQ-D-5 and PDQ-D-20 at each time point (correlation coefficient: baseline, 0.94; month 1, 0.94; month 2, 0.96; month 6, 0.96) and over time (0.92) (all p < 0.0001). Longitudinally, there were positive correlations between PDQ-D-5 scores versus those on the PHQ-9, MADRS, and SDS. Similarly, negative correlations were noted between PDQ-D-5 scores and EQ-5D-5L and DSST scores to a variable degree. There were moderate positive correlations over time between PDQ-D-5 and all WPAI subscale scores except those on absenteeism. PDQ-D-5 scores rated in Japanese patients with MDD were found to adequately represent scores on the PDQ-D-20. The short version also showed associations with several measures of functional outcome, depression severity and QoL. This validates the PDQ-D-5 as a feasible and clinically reliable tool to assess subjective experience on cognition, which is applicable to time-limited consultations. UMIN000024320.