Hydrolysis of Methionine- and Histidine-Containing Peptides Promoted by Dinuclear Platinum(II) Complexes with Benzodiazines as Bridging Ligands: Influence of Ligand Structure on the Catalytic Ability of Platinum(II) Complexes

Dinuclear platinum(II) complexes, [{Pt(en)Cl}2(μ-qx)]Cl2·2H2O (1), [{Pt(en)Cl}2(μ-qz)](ClO4)2 (2), and [{Pt(en)Cl}2(μ-phtz)]Cl2·4H2O (3), were synthesized and characterized by different spectroscopic techniques. The crystal structure of 1 was determined by single-crystal X-ray diffraction analysis,...

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Published in:Bioinorganic chemistry and applications 2018-01, Vol.2018 (2018), p.1-12
Main Authors: Rychlewska, Urszula, Glišić, Biljana Đ., Živković, Marija D., Warżajtis, Beata, Rajković, Snežana, Djuran, Miloš I.
Format: Article
Language:English
Subjects:
Amino acids
Catalysis
Catalytic activity
Cooperation
Crystal structure
Histidine
Hydrolysis
Ligands
Methionine
Nitrogen
Nitrogen atoms
NMR spectroscopy
Peptides
Physical chemistry
Physiology
Platinum
Single crystals
Studies
X-ray diffraction
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Summary:Dinuclear platinum(II) complexes, [{Pt(en)Cl}2(μ-qx)]Cl2·2H2O (1), [{Pt(en)Cl}2(μ-qz)](ClO4)2 (2), and [{Pt(en)Cl}2(μ-phtz)]Cl2·4H2O (3), were synthesized and characterized by different spectroscopic techniques. The crystal structure of 1 was determined by single-crystal X-ray diffraction analysis, while the DFT M06-2X method was applied in order to optimize the structures of 1–3. The chlorido Pt(II) complexes 1–3 were converted into the corresponding aqua species 1a–3a, and their reactions with an equimolar amount of Ac–L–Met–Gly and Ac–L–His–Gly dipeptides were studied by 1H NMR spectroscopy in the pH range 2.0 
ISSN:1565-3633
1687-479X
DOI:10.1155/2018/3294948