Monoclonal gammopathy of undetermined significance with multiple paraproteins: A population‐based screening study

Monoclonal gammopathy of undetermined significance (MGUS) is the precursor of multiple myeloma (MM) and related disorders. MGUS is characterized by asymptomatic paraproteinemia. In some cases, multiple paraproteins can be identified but the clinical implications of this phenomenon are poorly underst...

Full description

Saved in:
Bibliographic Details
Published in:HemaSphere 2024-11, Vol.8 (11), p.e70046-n/a
Main Authors: Rögnvaldsson, Sæmundur, Óskarsson, Jón Þ., Thorsteinsdóttir, Sigrun, Hultcrantz, Malin, Palmason, Robert, Sverrisdottir, Ingigerdur S., Eythorsson, Elias, Long, Thorir E., Olafsson, Isleifur, Thorsteinsdottir, Ingunn, Vidarsson, Brynjar, Onundarson, Pall T., Agnarsson, Bjarni A., Sigurdardottir, Margret, Jonsson, Asbjorn, Durie, Brian G. M., Harding, Stephen, Landgren, Ola, Love, Thorvardur J., Kristinsson, Sigurdur Y.
Format: Article
Language:English
Subjects:
Lymphoid Malignancies
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Monoclonal gammopathy of undetermined significance (MGUS) is the precursor of multiple myeloma (MM) and related disorders. MGUS is characterized by asymptomatic paraproteinemia. In some cases, multiple paraproteins can be identified but the clinical implications of this phenomenon are poorly understood. In this study, we aim to inform the approach to this challenging MGUS subgroup by utilizing data from iStopMM, a population‐based screening study and randomized trial of follow‐up strategies. In total, 75,422 Icelanders over the age of 40 were screened for MGUS with 3389 (4.4%) having at least one paraprotein of whom 303 (9%) had multiple paraproteins. IgM paraproteins were more common in those with multiple paraproteins (49% vs. 27% of paraproteins, p 
ISSN:2572-9241
2572-9241
DOI:10.1002/hem3.70046