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Apoptotic Effects of Anthocyanins from Vitis coignetiae Pulliat Are Enhanced by Augmented Enhancer of the Rudimentary Homolog (ERH) in Human Gastric Carcinoma MKN28 Cells
Evidence suggests that augmented expression of a certain gene can influence the efficacy of targeted and conventional chemotherapies. Here, we tested whether the high expression of enhancer of the rudimentary homolog (ERH), which serves as a prognostic factor in some cancers, can influence the effic...
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Published in: | International journal of molecular sciences 2021-03, Vol.22 (6), p.3030 |
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creator | Park, Cheol Lee, Won Sup Go, Se-Il Jeong, Sang-Ho Yoo, Jiyun Cha, Hee-Jae Lee, Young-Joon Kim, Heui-Soo Leem, Sun-Hee Kim, Hye Jung Kim, Gon Sup Hong, Soon-Chan Choi, Yung Hyun |
description | Evidence suggests that augmented expression of a certain gene can influence the efficacy of targeted and conventional chemotherapies. Here, we tested whether the high expression of enhancer of the rudimentary homolog (ERH), which serves as a prognostic factor in some cancers, can influence the efficacy of anthocyanins isolated from fruits of
, Meoru in Korea (AIMs) on human gastric cancer cells. The anticancer efficacy of AIMs was augmented in ERH-transfected MKN28 cells (E-MKN28 cells). Molecularly, ERH augmented AIM-induced caspase-dependent apoptosis by activating caspase-3 and -9. The ERH-augmented apoptotic effect was related to mitochondrial depolarization and inhibition of antiapoptotic proteins, XIAP, and Bcl-2. In addition, reactive oxygen species (ROS) generation was augmented in AIMs-treated E-MKN28 cells compared to AIMs-treated naïve MKN28 cells. In conclusion, ERH augmented AIM-induced caspase-dependent mitochondrial-related apoptosis in MKN28 cells. A decrease in expression of Bcl-2 and subsequent excessive ROS generation would be the mechanism for ERH-augmented mitochondrial-related apoptosis in AIMs-treated MKN28 cells. A decrease in expression of XIAP would be another mechanism for ERH-augmented caspase-dependent apoptosis in AIMs-treated MKN28 cells. |
doi_str_mv | 10.3390/ijms22063030 |
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, Meoru in Korea (AIMs) on human gastric cancer cells. The anticancer efficacy of AIMs was augmented in ERH-transfected MKN28 cells (E-MKN28 cells). Molecularly, ERH augmented AIM-induced caspase-dependent apoptosis by activating caspase-3 and -9. The ERH-augmented apoptotic effect was related to mitochondrial depolarization and inhibition of antiapoptotic proteins, XIAP, and Bcl-2. In addition, reactive oxygen species (ROS) generation was augmented in AIMs-treated E-MKN28 cells compared to AIMs-treated naïve MKN28 cells. In conclusion, ERH augmented AIM-induced caspase-dependent mitochondrial-related apoptosis in MKN28 cells. A decrease in expression of Bcl-2 and subsequent excessive ROS generation would be the mechanism for ERH-augmented mitochondrial-related apoptosis in AIMs-treated MKN28 cells. A decrease in expression of XIAP would be another mechanism for ERH-augmented caspase-dependent apoptosis in AIMs-treated MKN28 cells.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms22063030</identifier><identifier>PMID: 33809701</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Anthocyanins ; Anthocyanins - pharmacology ; Antibodies ; anticancer effects ; Apoptosis ; Apoptosis - drug effects ; Bcl-2 protein ; Cancer therapies ; Caspase-3 ; Caspases - metabolism ; Cell cycle ; Cell Cycle Proteins - metabolism ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Depolarization ; enhancer of the rudimentary homolog ; Enzyme Activation - drug effects ; Flow cytometry ; Gastric cancer ; Gene expression ; Growth factors ; Homology ; Humans ; Medical prognosis ; Membrane Potential, Mitochondrial - drug effects ; Metastasis ; Mitochondria ; MKN28 human gastric carcinoma cells ; Ovaries ; Plasmids ; Proteins ; Proto-Oncogene Proteins c-bcl-2 - metabolism ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - pathology ; Transcription Factors - metabolism ; Vitis - chemistry ; Vitis coignetiae Pulliat ; X-Linked Inhibitor of Apoptosis Protein - metabolism ; XIAP protein</subject><ispartof>International journal of molecular sciences, 2021-03, Vol.22 (6), p.3030</ispartof><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-9687b239a368eaef1b422aa7a46d256b868a34c95619b2d46cbef94b400f2f083</citedby><cites>FETCH-LOGICAL-c478t-9687b239a368eaef1b422aa7a46d256b868a34c95619b2d46cbef94b400f2f083</cites><orcidid>0000-0002-6963-2685 ; 0000-0002-1454-3124 ; 0000-0003-0863-1424 ; 0000-0002-0844-1009 ; 0000-0002-7067-6810</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2503358283/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2503358283?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33809701$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Cheol</creatorcontrib><creatorcontrib>Lee, Won Sup</creatorcontrib><creatorcontrib>Go, Se-Il</creatorcontrib><creatorcontrib>Jeong, Sang-Ho</creatorcontrib><creatorcontrib>Yoo, Jiyun</creatorcontrib><creatorcontrib>Cha, Hee-Jae</creatorcontrib><creatorcontrib>Lee, Young-Joon</creatorcontrib><creatorcontrib>Kim, Heui-Soo</creatorcontrib><creatorcontrib>Leem, Sun-Hee</creatorcontrib><creatorcontrib>Kim, Hye Jung</creatorcontrib><creatorcontrib>Kim, Gon Sup</creatorcontrib><creatorcontrib>Hong, Soon-Chan</creatorcontrib><creatorcontrib>Choi, Yung Hyun</creatorcontrib><title>Apoptotic Effects of Anthocyanins from Vitis coignetiae Pulliat Are Enhanced by Augmented Enhancer of the Rudimentary Homolog (ERH) in Human Gastric Carcinoma MKN28 Cells</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Evidence suggests that augmented expression of a certain gene can influence the efficacy of targeted and conventional chemotherapies. Here, we tested whether the high expression of enhancer of the rudimentary homolog (ERH), which serves as a prognostic factor in some cancers, can influence the efficacy of anthocyanins isolated from fruits of
, Meoru in Korea (AIMs) on human gastric cancer cells. The anticancer efficacy of AIMs was augmented in ERH-transfected MKN28 cells (E-MKN28 cells). Molecularly, ERH augmented AIM-induced caspase-dependent apoptosis by activating caspase-3 and -9. The ERH-augmented apoptotic effect was related to mitochondrial depolarization and inhibition of antiapoptotic proteins, XIAP, and Bcl-2. In addition, reactive oxygen species (ROS) generation was augmented in AIMs-treated E-MKN28 cells compared to AIMs-treated naïve MKN28 cells. In conclusion, ERH augmented AIM-induced caspase-dependent mitochondrial-related apoptosis in MKN28 cells. A decrease in expression of Bcl-2 and subsequent excessive ROS generation would be the mechanism for ERH-augmented mitochondrial-related apoptosis in AIMs-treated MKN28 cells. A decrease in expression of XIAP would be another mechanism for ERH-augmented caspase-dependent apoptosis in AIMs-treated MKN28 cells.</description><subject>Anthocyanins</subject><subject>Anthocyanins - pharmacology</subject><subject>Antibodies</subject><subject>anticancer effects</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Bcl-2 protein</subject><subject>Cancer therapies</subject><subject>Caspase-3</subject><subject>Caspases - metabolism</subject><subject>Cell cycle</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Depolarization</subject><subject>enhancer of the rudimentary homolog</subject><subject>Enzyme Activation - drug effects</subject><subject>Flow cytometry</subject><subject>Gastric cancer</subject><subject>Gene expression</subject><subject>Growth factors</subject><subject>Homology</subject><subject>Humans</subject><subject>Medical prognosis</subject><subject>Membrane Potential, Mitochondrial - drug effects</subject><subject>Metastasis</subject><subject>Mitochondria</subject><subject>MKN28 human gastric carcinoma cells</subject><subject>Ovaries</subject><subject>Plasmids</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins c-bcl-2 - metabolism</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - pathology</subject><subject>Transcription Factors - metabolism</subject><subject>Vitis - chemistry</subject><subject>Vitis coignetiae Pulliat</subject><subject>X-Linked Inhibitor of Apoptosis Protein - metabolism</subject><subject>XIAP protein</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkk9vEzEQxVcIREvhxhlZ4lIkAl7bu-u9VFpFoakof1QBV2vstRNHu3awvUj5SnxKHBKqlJPtmaef3jxPUbws8TtKW_zebsZICK4ppvhRcV4yQmYY183jk_tZ8SzGDcaEkqp9WpxRynHb4PK8-N1t_Tb5ZBVaGKNVisgb1Lm09moHzrqITPAj-mGTjUh5u3I6WdDo6zQMFhLqgkYLtwandI_kDnXTatQu5cexGvbAtNboburtvgVhh5Z-9INfocvF3fINsg4tpxEcuoaYQrYyh6Cs8yOgTx8_E47mehji8-KJgSHqF8fzovj-YfFtvpzdfrm-mXe3M8UanmZtzRtJaAu05hq0KWVOAaABVvekqiWvOVCm2qouW0l6ViupTcskw9gQgzm9KG4O3N7DRmyDHbNj4cGKvwUfVgJCDmzQQlPZc64qYxrGNAUOLW0kbwzpZV1WLLOuDqztJEfdqzx-gOEB9GHH2bVY-V-C7z-L4Qy4PAKC_znpmMRoo8pxgNN-ioJUmOdJWNVm6ev_pBs_BZej2qsorTjhNKveHlQq-BiDNvdmSiz2CyVOFyrLX50OcC_-t0H0D2uQx8c</recordid><startdate>20210316</startdate><enddate>20210316</enddate><creator>Park, Cheol</creator><creator>Lee, Won Sup</creator><creator>Go, Se-Il</creator><creator>Jeong, Sang-Ho</creator><creator>Yoo, Jiyun</creator><creator>Cha, Hee-Jae</creator><creator>Lee, Young-Joon</creator><creator>Kim, Heui-Soo</creator><creator>Leem, Sun-Hee</creator><creator>Kim, Hye Jung</creator><creator>Kim, Gon Sup</creator><creator>Hong, Soon-Chan</creator><creator>Choi, Yung Hyun</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-6963-2685</orcidid><orcidid>https://orcid.org/0000-0002-1454-3124</orcidid><orcidid>https://orcid.org/0000-0003-0863-1424</orcidid><orcidid>https://orcid.org/0000-0002-0844-1009</orcidid><orcidid>https://orcid.org/0000-0002-7067-6810</orcidid></search><sort><creationdate>20210316</creationdate><title>Apoptotic Effects of Anthocyanins from Vitis coignetiae Pulliat Are Enhanced by Augmented Enhancer of the Rudimentary Homolog (ERH) in Human Gastric Carcinoma MKN28 Cells</title><author>Park, Cheol ; Lee, Won Sup ; Go, Se-Il ; Jeong, Sang-Ho ; Yoo, Jiyun ; Cha, Hee-Jae ; Lee, Young-Joon ; Kim, Heui-Soo ; Leem, Sun-Hee ; Kim, Hye Jung ; Kim, Gon Sup ; Hong, Soon-Chan ; Choi, Yung Hyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-9687b239a368eaef1b422aa7a46d256b868a34c95619b2d46cbef94b400f2f083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anthocyanins</topic><topic>Anthocyanins - pharmacology</topic><topic>Antibodies</topic><topic>anticancer effects</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Bcl-2 protein</topic><topic>Cancer therapies</topic><topic>Caspase-3</topic><topic>Caspases - metabolism</topic><topic>Cell cycle</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Depolarization</topic><topic>enhancer of the rudimentary homolog</topic><topic>Enzyme Activation - drug effects</topic><topic>Flow cytometry</topic><topic>Gastric cancer</topic><topic>Gene expression</topic><topic>Growth factors</topic><topic>Homology</topic><topic>Humans</topic><topic>Medical prognosis</topic><topic>Membrane Potential, Mitochondrial - drug effects</topic><topic>Metastasis</topic><topic>Mitochondria</topic><topic>MKN28 human gastric carcinoma cells</topic><topic>Ovaries</topic><topic>Plasmids</topic><topic>Proteins</topic><topic>Proto-Oncogene Proteins c-bcl-2 - metabolism</topic><topic>Reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - pathology</topic><topic>Transcription Factors - metabolism</topic><topic>Vitis - chemistry</topic><topic>Vitis coignetiae Pulliat</topic><topic>X-Linked Inhibitor of Apoptosis Protein - metabolism</topic><topic>XIAP protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Cheol</creatorcontrib><creatorcontrib>Lee, Won Sup</creatorcontrib><creatorcontrib>Go, Se-Il</creatorcontrib><creatorcontrib>Jeong, Sang-Ho</creatorcontrib><creatorcontrib>Yoo, Jiyun</creatorcontrib><creatorcontrib>Cha, Hee-Jae</creatorcontrib><creatorcontrib>Lee, Young-Joon</creatorcontrib><creatorcontrib>Kim, Heui-Soo</creatorcontrib><creatorcontrib>Leem, Sun-Hee</creatorcontrib><creatorcontrib>Kim, Hye Jung</creatorcontrib><creatorcontrib>Kim, Gon Sup</creatorcontrib><creatorcontrib>Hong, Soon-Chan</creatorcontrib><creatorcontrib>Choi, Yung Hyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Cheol</au><au>Lee, Won Sup</au><au>Go, Se-Il</au><au>Jeong, Sang-Ho</au><au>Yoo, Jiyun</au><au>Cha, Hee-Jae</au><au>Lee, Young-Joon</au><au>Kim, Heui-Soo</au><au>Leem, Sun-Hee</au><au>Kim, Hye Jung</au><au>Kim, Gon Sup</au><au>Hong, Soon-Chan</au><au>Choi, Yung Hyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apoptotic Effects of Anthocyanins from Vitis coignetiae Pulliat Are Enhanced by Augmented Enhancer of the Rudimentary Homolog (ERH) in Human Gastric Carcinoma MKN28 Cells</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2021-03-16</date><risdate>2021</risdate><volume>22</volume><issue>6</issue><spage>3030</spage><pages>3030-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Evidence suggests that augmented expression of a certain gene can influence the efficacy of targeted and conventional chemotherapies. Here, we tested whether the high expression of enhancer of the rudimentary homolog (ERH), which serves as a prognostic factor in some cancers, can influence the efficacy of anthocyanins isolated from fruits of
, Meoru in Korea (AIMs) on human gastric cancer cells. The anticancer efficacy of AIMs was augmented in ERH-transfected MKN28 cells (E-MKN28 cells). Molecularly, ERH augmented AIM-induced caspase-dependent apoptosis by activating caspase-3 and -9. The ERH-augmented apoptotic effect was related to mitochondrial depolarization and inhibition of antiapoptotic proteins, XIAP, and Bcl-2. In addition, reactive oxygen species (ROS) generation was augmented in AIMs-treated E-MKN28 cells compared to AIMs-treated naïve MKN28 cells. In conclusion, ERH augmented AIM-induced caspase-dependent mitochondrial-related apoptosis in MKN28 cells. A decrease in expression of Bcl-2 and subsequent excessive ROS generation would be the mechanism for ERH-augmented mitochondrial-related apoptosis in AIMs-treated MKN28 cells. A decrease in expression of XIAP would be another mechanism for ERH-augmented caspase-dependent apoptosis in AIMs-treated MKN28 cells.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33809701</pmid><doi>10.3390/ijms22063030</doi><orcidid>https://orcid.org/0000-0002-6963-2685</orcidid><orcidid>https://orcid.org/0000-0002-1454-3124</orcidid><orcidid>https://orcid.org/0000-0003-0863-1424</orcidid><orcidid>https://orcid.org/0000-0002-0844-1009</orcidid><orcidid>https://orcid.org/0000-0002-7067-6810</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Anthocyanins Anthocyanins - pharmacology Antibodies anticancer effects Apoptosis Apoptosis - drug effects Bcl-2 protein Cancer therapies Caspase-3 Caspases - metabolism Cell cycle Cell Cycle Proteins - metabolism Cell Line, Tumor Cell Proliferation - drug effects Depolarization enhancer of the rudimentary homolog Enzyme Activation - drug effects Flow cytometry Gastric cancer Gene expression Growth factors Homology Humans Medical prognosis Membrane Potential, Mitochondrial - drug effects Metastasis Mitochondria MKN28 human gastric carcinoma cells Ovaries Plasmids Proteins Proto-Oncogene Proteins c-bcl-2 - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Transcription Factors - metabolism Vitis - chemistry Vitis coignetiae Pulliat X-Linked Inhibitor of Apoptosis Protein - metabolism XIAP protein |
title | Apoptotic Effects of Anthocyanins from Vitis coignetiae Pulliat Are Enhanced by Augmented Enhancer of the Rudimentary Homolog (ERH) in Human Gastric Carcinoma MKN28 Cells |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T16%3A55%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Apoptotic%20Effects%20of%20Anthocyanins%20from%20Vitis%20coignetiae%20Pulliat%20Are%20Enhanced%20by%20Augmented%20Enhancer%20of%20the%20Rudimentary%20Homolog%20(ERH)%20in%20Human%20Gastric%20Carcinoma%20MKN28%20Cells&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Park,%20Cheol&rft.date=2021-03-16&rft.volume=22&rft.issue=6&rft.spage=3030&rft.pages=3030-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms22063030&rft_dat=%3Cproquest_doaj_%3E2503358283%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c478t-9687b239a368eaef1b422aa7a46d256b868a34c95619b2d46cbef94b400f2f083%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2503358283&rft_id=info:pmid/33809701&rfr_iscdi=true |