An algal lectin griffithsin inhibits Hantaan virus infection in vitro and in vivo

Hantaan virus (HTNV) is the etiological pathogen of hemorrhagic fever with renal syndrome in East Asia. There are currently no effective therapeutics approved for HTNV and other hantavirus infections. We found that griffithsin (GRFT), an algae-derived lectin with broad-spectrum antiviral activity ag...

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Published in:Frontiers in cellular and infection microbiology 2022-12, Vol.12, p.881083-881083
Main Authors: Zhao, Yajing, Zhao, Ningbo, Cai, Yanxing, Zhang, Hui, Li, Jia, Liu, Jiaqi, Ye, Chuantao, Wang, Yuan, Dang, Yamei, Li, Wanying, Liu, He, Zhang, Lianqing, Li, Yuexiang, Zhang, Liang, Cheng, Linfeng, Dong, Yangchao, Xu, Zhikai, Lei, Yingfeng, Lu, Lu, Wang, Yingjuan, Ye, Wei, Zhang, Fanglin
Format: Article
Language:English
Subjects:
Animals
antivirals
Cellular and Infection Microbiology
griffithsin (GRFT)
Hantaan virus
hantavirus
Hantavirus Infections
hemorrhagic fever with renal syndrome (HFRS)
Hemorrhagic Fever with Renal Syndrome - drug therapy
lectin
Lectins - pharmacology
Mice
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Summary:Hantaan virus (HTNV) is the etiological pathogen of hemorrhagic fever with renal syndrome in East Asia. There are currently no effective therapeutics approved for HTNV and other hantavirus infections. We found that griffithsin (GRFT), an algae-derived lectin with broad-spectrum antiviral activity against various enveloped viruses, can inhibit the growth and spread of HTNV. experiments using recombinant vesicular stomatitis virus (rVSV) with HTNV glycoproteins as a model revealed that the GRFT inhibited the entry of rVSV-HTNV-G into host cells. In addition, we demonstrated that GRFT prevented authentic HTNV infection by binding to the viral -glycans. experiments showed that GRFT partially protected the suckling mice from death induced by intracranial exposure to HTNV. These results demonstrated that GRFT can be a promising agent for inhibiting HTNV infection.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2022.881083