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Age-Related Decline in Brain Myelination: Quantitative Macromolecular Proton Fraction Mapping, T2-FLAIR Hyperintensity Volume, and Anti-Myelin Antibodies Seven Years Apart
Age-related myelination decrease is considered one of the likely mechanisms of cognitive decline. The present preliminary study is based on the longitudinal assessment of global and regional myelination of the normal adult human brain using fast macromolecular fraction (MPF) mapping. Additional mark...
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| Published in: | Biomedicines 2024-01, Vol.12 (1), p.61 |
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| creator | Khodanovich, Marina Svetlik, Mikhail Naumova, Anna Kamaeva, Daria Usova, Anna Kudabaeva, Marina Anan'ina, Tatyana Wasserlauf, Irina Pashkevich, Valentina Moshkina, Marina Obukhovskaya, Victoria Kataeva, Nadezhda Levina, Anastasia Tumentceva, Yana Yarnykh, Vasily |
| description | Age-related myelination decrease is considered one of the likely mechanisms of cognitive decline. The present preliminary study is based on the longitudinal assessment of global and regional myelination of the normal adult human brain using fast macromolecular fraction (MPF) mapping. Additional markers were age-related changes in white matter (WM) hyperintensities on FLAIR-MRI and the levels of anti-myelin autoantibodies in serum. Eleven healthy subjects (33-60 years in the first study) were scanned twice, seven years apart. An age-related decrease in MPF was found in global WM, grey matter (GM), and mixed WM-GM, as well as in 48 out of 82 examined WM and GM regions. The greatest decrease in MPF was observed for the frontal WM (2-5%), genu of the corpus callosum (CC) (4.0%), and caudate nucleus (5.9%). The age-related decrease in MPF significantly correlated with an increase in the level of antibodies against myelin basic protein (MBP) in serum (r = 0.69 and r = 0.63 for global WM and mixed WM-GM, correspondingly). The volume of FLAIR hyperintensities increased with age but did not correlate with MPF changes and the levels of anti-myelin antibodies. MPF mapping showed high sensitivity to age-related changes in brain myelination, providing the feasibility of this method in clinics. |
| doi_str_mv | 10.3390/biomedicines12010061 |
| format | article |
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The present preliminary study is based on the longitudinal assessment of global and regional myelination of the normal adult human brain using fast macromolecular fraction (MPF) mapping. Additional markers were age-related changes in white matter (WM) hyperintensities on FLAIR-MRI and the levels of anti-myelin autoantibodies in serum. Eleven healthy subjects (33-60 years in the first study) were scanned twice, seven years apart. An age-related decrease in MPF was found in global WM, grey matter (GM), and mixed WM-GM, as well as in 48 out of 82 examined WM and GM regions. The greatest decrease in MPF was observed for the frontal WM (2-5%), genu of the corpus callosum (CC) (4.0%), and caudate nucleus (5.9%). The age-related decrease in MPF significantly correlated with an increase in the level of antibodies against myelin basic protein (MBP) in serum (r = 0.69 and r = 0.63 for global WM and mixed WM-GM, correspondingly). The volume of FLAIR hyperintensities increased with age but did not correlate with MPF changes and the levels of anti-myelin antibodies. MPF mapping showed high sensitivity to age-related changes in brain myelination, providing the feasibility of this method in clinics.</description><identifier>ISSN: 2227-9059</identifier><identifier>EISSN: 2227-9059</identifier><identifier>DOI: 10.3390/biomedicines12010061</identifier><identifier>PMID: 38255168</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Age ; Aging ; Antibodies ; Autoantibodies ; Autoimmunity ; Brain ; Brain mapping ; Brain research ; Caudate nucleus ; Cognitive ability ; Corpus callosum ; Histology ; Longitudinal studies ; macromolecular fraction mapping ; Macromolecules ; Magnetic resonance imaging ; Medical imaging ; Methods ; MPF ; myelin ; Myelin basic protein ; Myelin proteins ; Myelination ; Neuroimaging ; normal aging ; quantitative MRI ; Schizophrenia ; Substantia alba ; Substantia grisea ; Traumatic brain injury ; Viral antibodies</subject><ispartof>Biomedicines, 2024-01, Vol.12 (1), p.61</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c463t-4fff7eecb280470f046024a7f941d4183fe0337a18b486df4363bf6ca22c9ee13</cites><orcidid>0000-0003-2760-0252 ; 0000-0002-4021-5343 ; 0000-0003-1856-0674 ; 0009-0006-8817-0152</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2918586142/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918586142?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,37013,44590,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38255168$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khodanovich, Marina</creatorcontrib><creatorcontrib>Svetlik, Mikhail</creatorcontrib><creatorcontrib>Naumova, Anna</creatorcontrib><creatorcontrib>Kamaeva, Daria</creatorcontrib><creatorcontrib>Usova, Anna</creatorcontrib><creatorcontrib>Kudabaeva, Marina</creatorcontrib><creatorcontrib>Anan'ina, Tatyana</creatorcontrib><creatorcontrib>Wasserlauf, Irina</creatorcontrib><creatorcontrib>Pashkevich, Valentina</creatorcontrib><creatorcontrib>Moshkina, Marina</creatorcontrib><creatorcontrib>Obukhovskaya, Victoria</creatorcontrib><creatorcontrib>Kataeva, Nadezhda</creatorcontrib><creatorcontrib>Levina, Anastasia</creatorcontrib><creatorcontrib>Tumentceva, Yana</creatorcontrib><creatorcontrib>Yarnykh, Vasily</creatorcontrib><title>Age-Related Decline in Brain Myelination: Quantitative Macromolecular Proton Fraction Mapping, T2-FLAIR Hyperintensity Volume, and Anti-Myelin Antibodies Seven Years Apart</title><title>Biomedicines</title><addtitle>Biomedicines</addtitle><description>Age-related myelination decrease is considered one of the likely mechanisms of cognitive decline. The present preliminary study is based on the longitudinal assessment of global and regional myelination of the normal adult human brain using fast macromolecular fraction (MPF) mapping. Additional markers were age-related changes in white matter (WM) hyperintensities on FLAIR-MRI and the levels of anti-myelin autoantibodies in serum. Eleven healthy subjects (33-60 years in the first study) were scanned twice, seven years apart. An age-related decrease in MPF was found in global WM, grey matter (GM), and mixed WM-GM, as well as in 48 out of 82 examined WM and GM regions. The greatest decrease in MPF was observed for the frontal WM (2-5%), genu of the corpus callosum (CC) (4.0%), and caudate nucleus (5.9%). The age-related decrease in MPF significantly correlated with an increase in the level of antibodies against myelin basic protein (MBP) in serum (r = 0.69 and r = 0.63 for global WM and mixed WM-GM, correspondingly). The volume of FLAIR hyperintensities increased with age but did not correlate with MPF changes and the levels of anti-myelin antibodies. 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| source | Open Access: PubMed Central; Publicly Available Content Database |
| subjects | Age Aging Antibodies Autoantibodies Autoimmunity Brain Brain mapping Brain research Caudate nucleus Cognitive ability Corpus callosum Histology Longitudinal studies macromolecular fraction mapping Macromolecules Magnetic resonance imaging Medical imaging Methods MPF myelin Myelin basic protein Myelin proteins Myelination Neuroimaging normal aging quantitative MRI Schizophrenia Substantia alba Substantia grisea Traumatic brain injury Viral antibodies |
| title | Age-Related Decline in Brain Myelination: Quantitative Macromolecular Proton Fraction Mapping, T2-FLAIR Hyperintensity Volume, and Anti-Myelin Antibodies Seven Years Apart |
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