Presepsin as a diagnostic and prognostic biomarker of severe bacterial infections and COVID-19

We aimed to develop presepsin as a marker of diagnosis of severe infections of either bacterial and viral origin. The derivation cohort was recruited from 173 hospitalized patients with acute pancreatitis or post-operative fever or infection suspicion aggravated by at least one sign of the quick seq...

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Bibliographic Details
Published in:Scientific reports 2023-03, Vol.13 (1), p.3814-3814, Article 3814
Main Authors: Kyriazopoulou, Evdoxia, Leventogiannis, Konstantinos, Tavoulareas, Georgios, Mainas, Efstratios, Toutouzas, Konstantinos, Mathas, Christos, Prekates, Athanassios, Sakka, Vissaria, Panagopoulos, Periklis, Syrigos, Konstantinos, Giamarellos-Bourboulis, Evangelos J.
Format: Article
Language:English
Subjects:
692/53/2421
692/53/2422
692/53/2423
692/699/255/1318
692/699/255/2514
Acute Disease
Bacteria
Bacterial diseases
Bacterial Infections
Biomarkers
Coronaviruses
COVID-19
COVID-19 - diagnosis
COVID-19 Testing
Diagnosis
Emergency medical care
Humanities and Social Sciences
Humans
Infections
Lipopolysaccharide Receptors
Mechanical ventilation
Mortality
multidisciplinary
Pancreatitis
Peptide Fragments
Prognosis
Respiratory distress syndrome
Science
Science (multidisciplinary)
Sepsis
Sepsis - diagnosis
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Summary:We aimed to develop presepsin as a marker of diagnosis of severe infections of either bacterial and viral origin. The derivation cohort was recruited from 173 hospitalized patients with acute pancreatitis or post-operative fever or infection suspicion aggravated by at least one sign of the quick sequential organ failure assessment (qSOFA). The first validation cohort was recruited from 57 admissions at the emergency department with at least one qSOFA sign and the second validation cohort from 115 patients with COVID-19 pneumonia. Presepsin was measured in plasma by the PATHFAST assay. Concentrations more than 350 pg/ml had sensitivity 80.2% for sepsis diagnosis in the derivation cohort (adjusted odds ratio 4.47; p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-30807-5