Does Hypertension Affect the Recovery of Renal Functions after Reversal of Unilateral Ureteric Obstruction?

Research has demonstrated that hypertension can lead to an exaggeration in the renal functional and histological changes caused by ureteral obstruction. These changes were particularly observed shortly after the release of a relatively brief period of unilateral ureteral obstruction (UUO). However,...

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Published in:International journal of molecular sciences 2024-02, Vol.25 (3), p.1540
Main Authors: Hammad, Fayez T, Lubbad, Loay, Al-Salam, Suhail, Hammad, Waheed F, Yasin, Javed, Meeran, Mohamed Fizur Nagoor, Ojha, Shreesh, Arunachalam, Seenipandi, Hammad, Awwab F
Format: Article
Language:English
Subjects:
Albumin
Animals
Blood pressure
Creatinine
Gene expression
Glomerular Filtration Rate
Hypertension
Hypertension - physiopathology
Kidney - pathology
Kidneys
Rats
Rats, Inbred SHR
renal functions
reversible unilateral ureteral obstruction
Scientific equipment and supplies industry
Ureteral Obstruction - complications
Ureteral Obstruction - pathology
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Summary:Research has demonstrated that hypertension can lead to an exaggeration in the renal functional and histological changes caused by ureteral obstruction. These changes were particularly observed shortly after the release of a relatively brief period of unilateral ureteral obstruction (UUO). However, the long-term impact of hypertension on the recovery of renal functions has not been investigated beyond the immediate period after UUO reversal. In order to investigate this effect, a group of spontaneously hypertensive rats (G-SHR, n = 11) and a group of normotensive Wistar Kyoto rats (G-NTR, n = 11) were subjected to a 48 h reversible left UUO. The impact of UUO was then examined 45 days after the reversal of obstruction. The glomerular filtration rate, renal blood flow, and the fractional excretion of sodium in the post-obstructed left kidney (POK) showed similarities to the non-obstructed right kidney (NOK) in both groups. However, the changes in the albumin creatinine ratio, renal injury markers, pro-apoptotic markers, and histological changes in the G-SHR were much more pronounced compared to the G-NTR. We conclude that hypertension continues to have a significant impact on various aspects of renal injury and function, even several weeks after UUO reversal.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25031540