Multifaceted adult T-cell leukemia/lymphoma in India: a case series

Adult T-cell leukemia/lymphoma (ATL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1). India is considered as a nonendemic region for HTLV-1. Recent upsurge of cases have been noted in southern parts of India. The objective was to describe skin manifestations in various types of ATL. Cli...

Full description

Saved in:
Bibliographic Details
Published in:Indian journal of dermatology 2015-01, Vol.60 (1), p.103-103
Main Authors: Khader, Anza, Shaan, Mohamed, Balakrishnan, Sunitha, Ambooken, Betsy, Muhammed, Kunnummel, Rajan, Uma
Format: Article
Language:English
Subjects:
Adult T-cell leukemia/lymphoma
Biopsy
Bone marrow
Breast cancer
Case studies
E-IJD Case Series
India
Lymphatic system
Skin diseases
skin lesions
T cell lymphoma
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Adult T-cell leukemia/lymphoma (ATL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1). India is considered as a nonendemic region for HTLV-1. Recent upsurge of cases have been noted in southern parts of India. The objective was to describe skin manifestations in various types of ATL. Clinical examination, blood investigations, skin biopsies, lymph node biopsies, and immunohistochemistry were performed in five patients. Flow cytometry was performed in two cases. Serological testing was positive for HTLV-1 in all patients. All patients presented with skin lesions. Rare presentations of molluscum contagiosum like papules, purpuric macules and plaques, hypopigmented macules and verrucous papules were seen. Dermatophytic infections occurred in two patients. Mucosal lesion was seen in one patient. Histological features include dermal lymphoid infiltrate with or without epidermotropism. Presence of epidermotropism did not correlate with the severity of disease. All patients except one succumbed to illness within few months to 1 year period. ATL manifest in myriad presentations and skin lesions are often the earliest manifestation. Cutaneous manifestations of ATL vary from subtle hypopigmented macules to florid nodular lesions, and HTLV-1 screening need to be carried out in all doubtful cases.
ISSN:0019-5154
1998-3611
DOI:10.4103/0019-5154.147846