The modified Atkins diet in children with Prader-Willi syndrome

Prader-Willi Syndrome (PWS) is the most common genetic cause of obesity. Various dietary strategies have been used for weight management for people with PWS. This was a clinical feasibility study to test the use of the Modified Atkins Diet (low carbohydrate and high fat) for children with PWS ages 6...

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Bibliographic Details
Published in:Orphanet journal of rare diseases 2020-06, Vol.15 (1), p.1-135, Article 135
Main Authors: Felix, Grace, Kossoff, Eric, Barron, Bobbie, Krekel, Caitlin, Testa, Elizabeth Getzoff, Scheimann, Ann
Format: Article
Language:English
Subjects:
Anthropometry
Atkins diet
Behavior
Body weight
Calculi
Carbohydrates
Caregivers
Child health
Childhood obesity
Children
Creatinine
Diet
Dietitians
Families & family life
Feasibility studies
Food and nutrition
Hemoglobin
High carbohydrate diet
Hypercalciuria
Hyperphagia
Insulin
Ketogenic
Kidney stones
Laboratories
Lithiasis
Low carbohydrate diet
Low density lipoprotein
Low density lipoproteins
Medical research
Medical schools
Metabolism
Nutrient deficiency
Obesity
Overweight
Parents & parenting
Patients
Pediatric obesity
Pediatrics
Prader-Willi syndrome
Proteins
Psychologists
Rare diseases
Triglycerides
Urinalysis
Urine
Weight control
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Summary:Prader-Willi Syndrome (PWS) is the most common genetic cause of obesity. Various dietary strategies have been used for weight management for people with PWS. This was a clinical feasibility study to test the use of the Modified Atkins Diet (low carbohydrate and high fat) for children with PWS ages 6-12 years who were overweight/obese. Participants went on the Modified Atkins Diet for 4 months and then returned to have anthropometry repeated including repeat labs and behavior questionnaires. Seven children (ages 6-12) were enrolled in the study. Four participants completed the 4-month diet trial; two were unable to comply with the diet and stopped prematurely. One patient lost 2.9 kg; the others maintained their weight. Adverse effects were increases in LDL (expected based on larger studies) and hypercalciuria (with no renal stones) for one patient. Positive effects on hyperphagia and behavior were noted subjectively by families. The Modified Atkins Diet can be a feasible low carbohydrate option for children with Prader-Willi Syndrome for weight management. Long-term use of the diet in patients with Prader-Willi Syndrome needs to be studied further.
ISSN:1750-1172
1750-1172
DOI:10.1186/s13023-020-01412-w