Thermoresponsive graphene oxide – starch micro/nanohydrogel composite as biocompatible drug delivery system

Introduction: Stimuli-responsive hydrogels, which indicate a significant response to the environmental change (e.g., pH, temperature, light, …), have potential applications for tissue engineering, drug delivery systems, cell therapy, artificial muscles, biosensors, etc. Among the temperature-respons...

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Bibliographic Details
Published in:Bioimpacts 2017-01, Vol.7 (3), p.167-175
Main Authors: Sattari, Mina, Fathi, Marziyeh, Daei, Mansour, Erfan-Niya, Hamid, Barar, Jaleh, Entezami, Ali Akbar
Format: Article
Language:English
Subjects:
Biocompatibility
Biocompatible
Biodegradability
Biomedical materials
Biosensors
Cancer
Composite materials
Drug delivery
Drug delivery systems
Free radicals
Graphite
Hemolysis
Hydrogel composite
Hydrogels
Light effects
Mechanical properties
Muscles
Nanocomposites
Nanoparticles
Original Research
Phase transitions
Polymerization
Starch
Swelling/deswelling
Temperature effects
Thermal stability
Thermoresponsive
Tissue engineering
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Summary:Introduction: Stimuli-responsive hydrogels, which indicate a significant response to the environmental change (e.g., pH, temperature, light, …), have potential applications for tissue engineering, drug delivery systems, cell therapy, artificial muscles, biosensors, etc. Among the temperature-responsive materials, poly (N-isopropylacrylamide) (PNIPAAm) based hydrogels have been widely developed and their properties can be easily tailored by manipulating the properties of the hydrogel and the composite material. Graphene oxide (GO), as a multifunctional and biocompatible nanosheet, can efficiently improve the mechanical strength and response rate of PNIPAAm-based hydrogels. Here, hydrogel composites (HCs) of PNIPAAm with GO was developed using the modified starch as a biodegradable cross-linker.Methods: Micro/nanohydrogel composites were synthesized by free radical polymerization of NIPAAm in the suspension of different feed ratio of GO using maleate-modified starch (St-MA) as cross-linker and Tetrakis (hydroxymethyl) phosphonium chloride (THPC) as a strong oxygen scavenger. The HCs were characterized by FT-IR, DSC, TGA, SEM, and DLS. Also, the phase transition, swelling/deswelling behavior, hemocompatibility and biocompatibility of the synthesized HCs were investigated.Results: The thermal stability, phase transition temperature and internal network crosslinking of HCs increases with increasing of the GO feed ratio. Also, the swelling/deswelling, hemolysis, and MTT assays studies confirmed that the HCs are a fast response, hemocompatible and biocompatible materials.Conclusion: The employed facile approach for the synthesis of HCs yields an intelligent material with great potential for biomedical applications.
ISSN:2228-5660
2228-5652
2228-5660
DOI:10.15171/bi.2017.20