A systematic review and meta-analysis of the association between uric acid levels and chronic kidney disease

The function of uric acid (UA) in the genesis and evolution of chronic kidney disease (CKD) has motivated numerous studies, but the results remain inconclusive. We sought to conduct a systematic review and meta-analysis of cohort studies aiming to analyze the association of UA levels with the incide...

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Bibliographic Details
Published in:Scientific reports 2022-04, Vol.12 (1), p.6251-6251, Article 6251
Main Authors: Gonçalves, Danilo Lemes Naves, Moreira, Tiago Ricardo, da Silva, Luciana Saraiva
Format: Article
Language:English
Subjects:
692/4022/1585/104
692/699/1585/104
Cohort Studies
Female
Heterogeneity
Humanities and Social Sciences
Humans
Incidence
Kidney diseases
Kidneys
Male
Meta-analysis
multidisciplinary
Renal Insufficiency, Chronic - epidemiology
Renal Insufficiency, Chronic - etiology
Risk assessment
Science
Science (multidisciplinary)
Systematic review
Uric Acid
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Summary:The function of uric acid (UA) in the genesis and evolution of chronic kidney disease (CKD) has motivated numerous studies, but the results remain inconclusive. We sought to conduct a systematic review and meta-analysis of cohort studies aiming to analyze the association of UA levels with the incidence and progression of CKD. Pubmed/Medline, Lilacs/Bireme and Web of Science were searched to identify eligible studies, following the PRISMA protocol. Data were presented for CKD incidence and progression separately. For the meta-analysis, studies with data stratified by subgroups according to serum UA levels were selected. The inverse variance-weighted random effects model was used to generate a combined effect estimate. Meta-regressions were performed to identify the causes of heterogeneity. The Newcastle–Ottawa Scale was used to assess the risk of bias. The publication bias was tested by funnel plot and Egger’s test. Eighteen CKD incidence studies (n = 398,663) and six CKD progression studies (n = 13,575) were included. An inverse relationship was observed between UA levels and protection from CKD incidence and progression. Lower UA levels were protective for the risk of CKD incidence (RR 0.65 [95% CI 0.56–0.75]) and progression (RR 0.55 [95% CI 0.44–0.68]). UA seems to be implicated both in the genesis of CKD and its evolution.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-10118-x