Dietary Iron Restriction Improves Muscle Function, Dyslipidemia, and Decreased Muscle Oxidative Stress in Streptozotocin-Induced Diabetic Rats

Diabetes mellitus is a chronic degenerative disease characterized by hyperglycemia and oxidative stress. Iron catalyzes free radical overproduction. High iron concentrations have previously been reported to promote an increase in oxidative stress; however, the effect of iron restriction in diabetes...

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Bibliographic Details
Published in:Antioxidants 2022-04, Vol.11 (4), p.731
Main Authors: Vargas-Vargas, Manuel Alejandro, Saavedra-Molina, Alfredo, Gómez-Barroso, Mariana, Peña-Montes, Donovan, Cortés-Rojo, Christian, Miguel, Huerta, Trujillo, Xochitl, Montoya-Pérez, Rocío
Format: Article
Language:English
Subjects:
Acids
Diabetes
Diabetes mellitus
Diet
Dyslipidemia
fatigue
Glucose
Hemoglobin
Hyperglycemia
Iron
Laboratory animals
Lipid peroxidation
Lipids
Lipoproteins
Muscle fatigue
Muscle function
Muscle strength
Muscles
Oxidants
Oxidative stress
Potassium
Proteins
Rodents
Streptozocin
Tension tests
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Summary:Diabetes mellitus is a chronic degenerative disease characterized by hyperglycemia and oxidative stress. Iron catalyzes free radical overproduction. High iron concentrations have previously been reported to promote an increase in oxidative stress; however, the effect of iron restriction in diabetes has not yet been explored, so we tested to see if iron restriction in diabetic rats reduces oxidative damage and improved muscle function. Wistar rats were assigned to 4 groups: Control; Diabetic; Diabetic rats with a high iron diet, and Diabetic with dietary iron restriction. After 8 weeks the rats were sacrificed, the muscles were extracted to prepare homogenates, and serum was obtained for biochemical measurements. Low iron diabetic rats showed an increase in the development of muscle strength in both muscles. Dietary iron restriction decreased triglyceride concentrations compared to the untreated diabetic rats and the levels of extremely low-density lipoproteins. Aggravation of lipid peroxidation was observed in the diabetic group with a high iron diet, while these levels remained low with iron restriction. Iron restriction improved muscle strength development and reduced fatigue times; this was related to better lipid profile control and decreased oxidant stress markers.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox11040731