Critical roles of lncRNA-mediated autophagy in urologic malignancies

Urologic oncology is a significant public health concern on a global scale. Recent research indicates that long chain non-coding RNAs (lncRNAs) and autophagy play crucial roles in various cancers, including urologic malignancies. This article provides a summary of the latest research findings, sugge...

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Bibliographic Details
Published in:Frontiers in pharmacology 2024-06, Vol.15, p.1405199
Main Authors: Gan, Lifeng, Zheng, Liying, Zou, Junrong, Luo, Peiyue, Chen, Tao, Zou, Jun, Li, Wei, Chen, Qi, Cheng, Le, Zhang, Fangtao, Qian, Biao
Format: Article
Language:English
Subjects:
autophagy
lncRNA
molecular mechanisms
pathways
Pharmacology
urologic oncologies
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Summary:Urologic oncology is a significant public health concern on a global scale. Recent research indicates that long chain non-coding RNAs (lncRNAs) and autophagy play crucial roles in various cancers, including urologic malignancies. This article provides a summary of the latest research findings, suggesting that lncRNA-mediated autophagy could either suppress or promote tumors in prostate, kidney, and bladder cancers. The intricate network involving different lncRNAs, target genes, and mediated signaling pathways plays a crucial role in urological malignancies by modulating the autophagic process. Dysregulated expression of lncRNAs can disrupt autophagy, leading to tumorigenesis, progression, and enhanced resistance to therapy. Consequently, targeting particular lncRNAs that control autophagy could serve as a dependable diagnostic tool and a promising prognostic biomarker in urologic oncology, while also holding potential as an effective therapeutic approach.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2024.1405199