Effects of Radon From Hot Springs on Lymphocyte Subsets in Peripheral Blood

• Published in: Dose-response 2020-01, Vol.18 (1), p.1559325820902338-1559325820902338
• Main Authors: Piao, Chunnan, Tian, Mei, Gao, Hongjun, Gao, Yanxiao, Ruan, Jianlei, Wu, Lina, Gao, Gang, Yi, Lirong, Liu, Jianxiang
• Format: Article
• Language: English
• Subjects: Immunity (Disease); Lymphocytes; Original; Radon
• ISSN: 1559-3258; 1559-3258
• DOI: 10.1177/1559325820902338

Objective: To analyze changes in immune functions by detecting lymphocyte subsets in the peripheral blood of residents in the vicinity of radon from hot springs. Methods: Two groups were randomly selected; 61 residents in the vicinity of the hot springs were assigned to the radon group, and 51 residents with a similar lifestyle and habits but no contact with hot springs were assigned to the control group. The percentages of lymphocyte subsets (CD3+, CD4+CD8−, CD4−CD8+, CD4+/CD8+, and TCR/CD3) in the 2 groups were evaluated on a FACS Aria flow cytometer. The absolute values of lymphocytes (LYMPH#) and percentages of lymphocytes (LYMPH%) were measured by an automatic blood analyzer. Results: In the radon group, the numbers of CD3+ (Z = −0.140, P > .05) and CD4+CD8− (Z = −0.964, P > .05) T cells were higher, as compared with the controls, but this difference was not significant. In addition, the number of CD4−CD8+ (t = −2.141, P < .05) T cells was significantly lower in the radon group. Furthermore, the average ratios of CD4+/CD8+ (t = −2.201, P < .05) and TCR/CD3 (t = 2.047, P < .05) cells were significantly higher in the radon group than in the controls. Compared with the control group, the LYMPH# (t = −0.485, P > .05) and LYMPH% (Z = −0.835, P > .05) showed no significant change. Conclusion: Radon-rich hot springs could alter the proportions of lymphocyte subsets and possibly affect immunologic functions.