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Effects of Radon From Hot Springs on Lymphocyte Subsets in Peripheral Blood
Objective: To analyze changes in immune functions by detecting lymphocyte subsets in the peripheral blood of residents in the vicinity of radon from hot springs. Methods: Two groups were randomly selected; 61 residents in the vicinity of the hot springs were assigned to the radon group, and 51 resid...
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| Published in: | Dose-response 2020-01, Vol.18 (1), p.1559325820902338-1559325820902338 |
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| container_title | Dose-response |
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| creator | Piao, Chunnan Tian, Mei Gao, Hongjun Gao, Yanxiao Ruan, Jianlei Wu, Lina Gao, Gang Yi, Lirong Liu, Jianxiang |
| description | Objective:
To analyze changes in immune functions by detecting lymphocyte subsets in the peripheral blood of residents in the vicinity of radon from hot springs.
Methods:
Two groups were randomly selected; 61 residents in the vicinity of the hot springs were assigned to the radon group, and 51 residents with a similar lifestyle and habits but no contact with hot springs were assigned to the control group. The percentages of lymphocyte subsets (CD3+, CD4+CD8−, CD4−CD8+, CD4+/CD8+, and TCR/CD3) in the 2 groups were evaluated on a FACS Aria flow cytometer. The absolute values of lymphocytes (LYMPH#) and percentages of lymphocytes (LYMPH%) were measured by an automatic blood analyzer.
Results:
In the radon group, the numbers of CD3+ (Z = −0.140, P > .05) and CD4+CD8− (Z = −0.964, P > .05) T cells were higher, as compared with the controls, but this difference was not significant. In addition, the number of CD4−CD8+ (t = −2.141, P < .05) T cells was significantly lower in the radon group. Furthermore, the average ratios of CD4+/CD8+ (t = −2.201, P < .05) and TCR/CD3 (t = 2.047, P < .05) cells were significantly higher in the radon group than in the controls. Compared with the control group, the LYMPH# (t = −0.485, P > .05) and LYMPH% (Z = −0.835, P > .05) showed no significant change.
Conclusion:
Radon-rich hot springs could alter the proportions of lymphocyte subsets and possibly affect immunologic functions. |
| doi_str_mv | 10.1177/1559325820902338 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_e421723fddbb449a85dca1cca48c0bbc</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1559325820902338</sage_id><doaj_id>oai_doaj_org_article_e421723fddbb449a85dca1cca48c0bbc</doaj_id><sourcerecordid>2385916782</sourcerecordid><originalsourceid>FETCH-LOGICAL-c528t-515a6b157d0a84c32717e3ae72c38c6655e89cdf4ed06b82560f7501dfe1ad023</originalsourceid><addsrcrecordid>eNp1kUmP1DAQhS0EYha4c0KWuHAJeIm3CxKMZtO0NCMGzpZjV7rTSuLGTpD63-Omh9kkTraqXn2u54fQO0o-UarUZyqE4UxoRgxhnOsX6HBXqna1l4_uB-go5zUhtVCcvkYHnBFFhRGH6Oq0bcFPGccWf3chjvgsxQFfxAnfblI3LktnxIvtsFlFv50A385NhqLvRnwDqdusILkef-tjDG_Qq9b1Gd7encfo59npj5OLanF9fnnydVF5wfRUCSqcbKhQgThde84UVcAdKOa59lIKAdr40NYQiGw0E5K0ShAaWqAuFJ_H6HLPDdGtbdlycGlro-vs30JMS-vS1PkeLNSMKsbbEJqmro3TInhHvXe19qRpfGF92bM2czNA8DBOxc8T6NPO2K3sMv620hhlpC6Aj3eAFH_NkCc7dNlD37sR4pwt40ILqampi_TDM-k6zmksX1VUWhgqld65I3uVTzHnBO39MpTYXer2eepl5P1jE_cD_2IugmovyG4JD6_-F_gH28yz8A</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2385916782</pqid></control><display><type>article</type><title>Effects of Radon From Hot Springs on Lymphocyte Subsets in Peripheral Blood</title><source>SAGE Open Access</source><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Piao, Chunnan ; Tian, Mei ; Gao, Hongjun ; Gao, Yanxiao ; Ruan, Jianlei ; Wu, Lina ; Gao, Gang ; Yi, Lirong ; Liu, Jianxiang</creator><creatorcontrib>Piao, Chunnan ; Tian, Mei ; Gao, Hongjun ; Gao, Yanxiao ; Ruan, Jianlei ; Wu, Lina ; Gao, Gang ; Yi, Lirong ; Liu, Jianxiang</creatorcontrib><description>Objective:
To analyze changes in immune functions by detecting lymphocyte subsets in the peripheral blood of residents in the vicinity of radon from hot springs.
Methods:
Two groups were randomly selected; 61 residents in the vicinity of the hot springs were assigned to the radon group, and 51 residents with a similar lifestyle and habits but no contact with hot springs were assigned to the control group. The percentages of lymphocyte subsets (CD3+, CD4+CD8−, CD4−CD8+, CD4+/CD8+, and TCR/CD3) in the 2 groups were evaluated on a FACS Aria flow cytometer. The absolute values of lymphocytes (LYMPH#) and percentages of lymphocytes (LYMPH%) were measured by an automatic blood analyzer.
Results:
In the radon group, the numbers of CD3+ (Z = −0.140, P > .05) and CD4+CD8− (Z = −0.964, P > .05) T cells were higher, as compared with the controls, but this difference was not significant. In addition, the number of CD4−CD8+ (t = −2.141, P < .05) T cells was significantly lower in the radon group. Furthermore, the average ratios of CD4+/CD8+ (t = −2.201, P < .05) and TCR/CD3 (t = 2.047, P < .05) cells were significantly higher in the radon group than in the controls. Compared with the control group, the LYMPH# (t = −0.485, P > .05) and LYMPH% (Z = −0.835, P > .05) showed no significant change.
Conclusion:
Radon-rich hot springs could alter the proportions of lymphocyte subsets and possibly affect immunologic functions.</description><identifier>ISSN: 1559-3258</identifier><identifier>EISSN: 1559-3258</identifier><identifier>DOI: 10.1177/1559325820902338</identifier><identifier>PMID: 32071595</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Immunity (Disease) ; Lymphocytes ; Original ; Radon</subject><ispartof>Dose-response, 2020-01, Vol.18 (1), p.1559325820902338-1559325820902338</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020.</rights><rights>The Author(s) 2020. This work is licensed under the Creative Commons Attribution – Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2020 2020 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-515a6b157d0a84c32717e3ae72c38c6655e89cdf4ed06b82560f7501dfe1ad023</citedby><cites>FETCH-LOGICAL-c528t-515a6b157d0a84c32717e3ae72c38c6655e89cdf4ed06b82560f7501dfe1ad023</cites><orcidid>0000-0002-4349-9564 ; 0000-0002-3552-052X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997968/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2385916782?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,21946,25732,27832,27903,27904,36991,36992,44569,44924,45312,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32071595$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Piao, Chunnan</creatorcontrib><creatorcontrib>Tian, Mei</creatorcontrib><creatorcontrib>Gao, Hongjun</creatorcontrib><creatorcontrib>Gao, Yanxiao</creatorcontrib><creatorcontrib>Ruan, Jianlei</creatorcontrib><creatorcontrib>Wu, Lina</creatorcontrib><creatorcontrib>Gao, Gang</creatorcontrib><creatorcontrib>Yi, Lirong</creatorcontrib><creatorcontrib>Liu, Jianxiang</creatorcontrib><title>Effects of Radon From Hot Springs on Lymphocyte Subsets in Peripheral Blood</title><title>Dose-response</title><addtitle>Dose Response</addtitle><description>Objective:
To analyze changes in immune functions by detecting lymphocyte subsets in the peripheral blood of residents in the vicinity of radon from hot springs.
Methods:
Two groups were randomly selected; 61 residents in the vicinity of the hot springs were assigned to the radon group, and 51 residents with a similar lifestyle and habits but no contact with hot springs were assigned to the control group. The percentages of lymphocyte subsets (CD3+, CD4+CD8−, CD4−CD8+, CD4+/CD8+, and TCR/CD3) in the 2 groups were evaluated on a FACS Aria flow cytometer. The absolute values of lymphocytes (LYMPH#) and percentages of lymphocytes (LYMPH%) were measured by an automatic blood analyzer.
Results:
In the radon group, the numbers of CD3+ (Z = −0.140, P > .05) and CD4+CD8− (Z = −0.964, P > .05) T cells were higher, as compared with the controls, but this difference was not significant. In addition, the number of CD4−CD8+ (t = −2.141, P < .05) T cells was significantly lower in the radon group. Furthermore, the average ratios of CD4+/CD8+ (t = −2.201, P < .05) and TCR/CD3 (t = 2.047, P < .05) cells were significantly higher in the radon group than in the controls. Compared with the control group, the LYMPH# (t = −0.485, P > .05) and LYMPH% (Z = −0.835, P > .05) showed no significant change.
Conclusion:
Radon-rich hot springs could alter the proportions of lymphocyte subsets and possibly affect immunologic functions.</description><subject>Immunity (Disease)</subject><subject>Lymphocytes</subject><subject>Original</subject><subject>Radon</subject><issn>1559-3258</issn><issn>1559-3258</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp1kUmP1DAQhS0EYha4c0KWuHAJeIm3CxKMZtO0NCMGzpZjV7rTSuLGTpD63-Omh9kkTraqXn2u54fQO0o-UarUZyqE4UxoRgxhnOsX6HBXqna1l4_uB-go5zUhtVCcvkYHnBFFhRGH6Oq0bcFPGccWf3chjvgsxQFfxAnfblI3LktnxIvtsFlFv50A385NhqLvRnwDqdusILkef-tjDG_Qq9b1Gd7encfo59npj5OLanF9fnnydVF5wfRUCSqcbKhQgThde84UVcAdKOa59lIKAdr40NYQiGw0E5K0ShAaWqAuFJ_H6HLPDdGtbdlycGlro-vs30JMS-vS1PkeLNSMKsbbEJqmro3TInhHvXe19qRpfGF92bM2czNA8DBOxc8T6NPO2K3sMv620hhlpC6Aj3eAFH_NkCc7dNlD37sR4pwt40ILqampi_TDM-k6zmksX1VUWhgqld65I3uVTzHnBO39MpTYXer2eepl5P1jE_cD_2IugmovyG4JD6_-F_gH28yz8A</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Piao, Chunnan</creator><creator>Tian, Mei</creator><creator>Gao, Hongjun</creator><creator>Gao, Yanxiao</creator><creator>Ruan, Jianlei</creator><creator>Wu, Lina</creator><creator>Gao, Gang</creator><creator>Yi, Lirong</creator><creator>Liu, Jianxiang</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><general>SAGE Publishing</general><scope>AFRWT</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4349-9564</orcidid><orcidid>https://orcid.org/0000-0002-3552-052X</orcidid></search><sort><creationdate>20200101</creationdate><title>Effects of Radon From Hot Springs on Lymphocyte Subsets in Peripheral Blood</title><author>Piao, Chunnan ; Tian, Mei ; Gao, Hongjun ; Gao, Yanxiao ; Ruan, Jianlei ; Wu, Lina ; Gao, Gang ; Yi, Lirong ; Liu, Jianxiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-515a6b157d0a84c32717e3ae72c38c6655e89cdf4ed06b82560f7501dfe1ad023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Immunity (Disease)</topic><topic>Lymphocytes</topic><topic>Original</topic><topic>Radon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Piao, Chunnan</creatorcontrib><creatorcontrib>Tian, Mei</creatorcontrib><creatorcontrib>Gao, Hongjun</creatorcontrib><creatorcontrib>Gao, Yanxiao</creatorcontrib><creatorcontrib>Ruan, Jianlei</creatorcontrib><creatorcontrib>Wu, Lina</creatorcontrib><creatorcontrib>Gao, Gang</creatorcontrib><creatorcontrib>Yi, Lirong</creatorcontrib><creatorcontrib>Liu, Jianxiang</creatorcontrib><collection>SAGE Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Databases</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Dose-response</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Piao, Chunnan</au><au>Tian, Mei</au><au>Gao, Hongjun</au><au>Gao, Yanxiao</au><au>Ruan, Jianlei</au><au>Wu, Lina</au><au>Gao, Gang</au><au>Yi, Lirong</au><au>Liu, Jianxiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Radon From Hot Springs on Lymphocyte Subsets in Peripheral Blood</atitle><jtitle>Dose-response</jtitle><addtitle>Dose Response</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>18</volume><issue>1</issue><spage>1559325820902338</spage><epage>1559325820902338</epage><pages>1559325820902338-1559325820902338</pages><issn>1559-3258</issn><eissn>1559-3258</eissn><abstract>Objective:
To analyze changes in immune functions by detecting lymphocyte subsets in the peripheral blood of residents in the vicinity of radon from hot springs.
Methods:
Two groups were randomly selected; 61 residents in the vicinity of the hot springs were assigned to the radon group, and 51 residents with a similar lifestyle and habits but no contact with hot springs were assigned to the control group. The percentages of lymphocyte subsets (CD3+, CD4+CD8−, CD4−CD8+, CD4+/CD8+, and TCR/CD3) in the 2 groups were evaluated on a FACS Aria flow cytometer. The absolute values of lymphocytes (LYMPH#) and percentages of lymphocytes (LYMPH%) were measured by an automatic blood analyzer.
Results:
In the radon group, the numbers of CD3+ (Z = −0.140, P > .05) and CD4+CD8− (Z = −0.964, P > .05) T cells were higher, as compared with the controls, but this difference was not significant. In addition, the number of CD4−CD8+ (t = −2.141, P < .05) T cells was significantly lower in the radon group. Furthermore, the average ratios of CD4+/CD8+ (t = −2.201, P < .05) and TCR/CD3 (t = 2.047, P < .05) cells were significantly higher in the radon group than in the controls. Compared with the control group, the LYMPH# (t = −0.485, P > .05) and LYMPH% (Z = −0.835, P > .05) showed no significant change.
Conclusion:
Radon-rich hot springs could alter the proportions of lymphocyte subsets and possibly affect immunologic functions.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>32071595</pmid><doi>10.1177/1559325820902338</doi><orcidid>https://orcid.org/0000-0002-4349-9564</orcidid><orcidid>https://orcid.org/0000-0002-3552-052X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Dose-response, 2020-01, Vol.18 (1), p.1559325820902338-1559325820902338 |
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| language | eng |
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| source | SAGE Open Access; Publicly Available Content Database; PubMed Central |
| subjects | Immunity (Disease) Lymphocytes Original Radon |
| title | Effects of Radon From Hot Springs on Lymphocyte Subsets in Peripheral Blood |
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