Measurement of fasting breath hydrogen concentration as a simple diagnostic method for pancreatic exocrine insufficiency

Pancreatic exocrine insufficiency (PEI) is associated with the outcome of pancreatic disease. However, there is no method for assessing PEI that can be used noninvasively and easily for outpatient. It has been reported that changes in intestinal bacteria caused by PEI may increase breath hydrogen co...

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Bibliographic Details
Published in:BMC gastroenterology 2021-05, Vol.21 (1), p.211-211, Article 211
Main Authors: Uetsuki, Kota, Kawashima, Hiroki, Ohno, Eizaburo, Ishikawa, Takuya, Iida, Tadashi, Yamamoto, Kenta, Furukawa, Kazuhiro, Nakamura, Masanao, Honda, Takashi, Ishigami, Masatoshi, Hirooka, Yoshiki, Fujishiro, Mitsuhiro
Format: Article
Language:English
Subjects:
Alcohol use
Bacteria
Breath Tests
Calcification
Carbon monoxide
Clostridium
Cysts
Diabetes
Diagnosis
Disease
Endoscopy
Enzymes
Excretion
Exocrine Pancreatic Insufficiency - diagnosis
Fasting
Fasting breath hydrogen concentration
Feces
Gastroenterology
Health aspects
Hemoglobin
Humans
Hydrogen
Hypertension
Intestine
Laboratory testing
Lactose
Methods
Microbiomes
Non-invasive measurement
Pancreas
Pancreatic disease
Pancreatic Diseases
Pancreatic exocrine insufficiency
Pancreatic insufficiency
Physiological aspects
rRNA
Statistical analysis
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Summary:Pancreatic exocrine insufficiency (PEI) is associated with the outcome of pancreatic disease. However, there is no method for assessing PEI that can be used noninvasively and easily for outpatient. It has been reported that changes in intestinal bacteria caused by PEI may increase breath hydrogen concentration (BHC) levels during glucose or lactose loading. We have evaluated the usefulness of fasting breath hydrogen concentration (FBHC) measurement without glucose loading for the evaluation of PEI. Sixty patients underwent FBHC measurement, BT-PABA testing, and microbiome analysis. They were classified into PEI group (PABA excretion rate 
ISSN:1471-230X
1471-230X
DOI:10.1186/s12876-021-01776-8