Measurement of fasting breath hydrogen concentration as a simple diagnostic method for pancreatic exocrine insufficiency

Pancreatic exocrine insufficiency (PEI) is associated with the outcome of pancreatic disease. However, there is no method for assessing PEI that can be used noninvasively and easily for outpatient. It has been reported that changes in intestinal bacteria caused by PEI may increase breath hydrogen co...

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Published in:BMC gastroenterology 2021-05, Vol.21 (1), p.211-211, Article 211
Main Authors: Uetsuki, Kota, Kawashima, Hiroki, Ohno, Eizaburo, Ishikawa, Takuya, Iida, Tadashi, Yamamoto, Kenta, Furukawa, Kazuhiro, Nakamura, Masanao, Honda, Takashi, Ishigami, Masatoshi, Hirooka, Yoshiki, Fujishiro, Mitsuhiro
Format: Article
Language:English
Subjects:
Alcohol use
Bacteria
Breath Tests
Calcification
Carbon monoxide
Clostridium
Cysts
Diabetes
Diagnosis
Disease
Endoscopy
Enzymes
Excretion
Exocrine Pancreatic Insufficiency - diagnosis
Fasting
Fasting breath hydrogen concentration
Feces
Gastroenterology
Health aspects
Hemoglobin
Humans
Hydrogen
Hypertension
Intestine
Laboratory testing
Lactose
Methods
Microbiomes
Non-invasive measurement
Pancreas
Pancreatic disease
Pancreatic Diseases
Pancreatic exocrine insufficiency
Pancreatic insufficiency
Physiological aspects
rRNA
Statistical analysis
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cited_by cdi_FETCH-LOGICAL-c563t-a8dc2a2cefd82da2ded9dcad76f26264fdb82c8283b405a47afdd587d09c9f393
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container_title BMC gastroenterology
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creator Uetsuki, Kota
Kawashima, Hiroki
Ohno, Eizaburo
Ishikawa, Takuya
Iida, Tadashi
Yamamoto, Kenta
Furukawa, Kazuhiro
Nakamura, Masanao
Honda, Takashi
Ishigami, Masatoshi
Hirooka, Yoshiki
Fujishiro, Mitsuhiro
description Pancreatic exocrine insufficiency (PEI) is associated with the outcome of pancreatic disease. However, there is no method for assessing PEI that can be used noninvasively and easily for outpatient. It has been reported that changes in intestinal bacteria caused by PEI may increase breath hydrogen concentration (BHC) levels during glucose or lactose loading. We have evaluated the usefulness of fasting breath hydrogen concentration (FBHC) measurement without glucose loading for the evaluation of PEI. Sixty patients underwent FBHC measurement, BT-PABA testing, and microbiome analysis. They were classified into PEI group (PABA excretion rate 
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However, there is no method for assessing PEI that can be used noninvasively and easily for outpatient. It has been reported that changes in intestinal bacteria caused by PEI may increase breath hydrogen concentration (BHC) levels during glucose or lactose loading. We have evaluated the usefulness of fasting breath hydrogen concentration (FBHC) measurement without glucose loading for the evaluation of PEI. Sixty patients underwent FBHC measurement, BT-PABA testing, and microbiome analysis. They were classified into PEI group (PABA excretion rate < 73.4%, n = 30) and non-PEI group (n = 30). The FBHC of the two groups were compared, and the diagnostic ability of PEI by them was evaluated. The 16 s rRNA (V3-V4) from fecal samples was analyzed by MiSeq. FBHC levels was higher in the PEI group 15.70 (1.4 to 77.0) ppm than in the non-PEI group 2.80 (0.7 to 28.2) ppm (P < 0.0001). FBHC was negatively correlated with PABA excretion rate (r =  - 0.523, P < 0.001). The cutoff value of FBHC of 10.7 ppm (95% CI: 0.678-0.913, P < 0.001) showed a sensitivity of 73.3% and specificity of 83.3% for PEI diagnosis. In the PEI group, there was a significant increase of relative abundance of phylum Firmicutes (P < 0.05) and the genus Clostridium (P < 0.05). FBHC shows good potential as a simple and repeatable test for the diagnosis of PEI. 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subjects Alcohol use
Bacteria
Breath Tests
Calcification
Carbon monoxide
Clostridium
Cysts
Diabetes
Diagnosis
Disease
Endoscopy
Enzymes
Excretion
Exocrine Pancreatic Insufficiency - diagnosis
Fasting
Fasting breath hydrogen concentration
Feces
Gastroenterology
Health aspects
Hemoglobin
Humans
Hydrogen
Hypertension
Intestine
Laboratory testing
Lactose
Methods
Microbiomes
Non-invasive measurement
Pancreas
Pancreatic disease
Pancreatic Diseases
Pancreatic exocrine insufficiency
Pancreatic insufficiency
Physiological aspects
rRNA
Statistical analysis
title Measurement of fasting breath hydrogen concentration as a simple diagnostic method for pancreatic exocrine insufficiency
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