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Roles of Dermcidin, Salusin-α, Salusin-β and TNF-α in the Pathogenesis of Human Brucellosis

Brucella spp. are facultative intracellular pathogens that can cause chronic infections in many tissues and organs. To investigate serum dermcidin, salusin-alpha, salusin-beta and TNF-alpha levels and their correlation with each other in patients with acute brucellosis. From 50 patients hospitalized...

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Bibliographic Details
Published in:Iranian journal of immunology 2019-06, Vol.16 (2), p.182-189
Main Authors: Sağmak Tartar, Ayşe, Özer Balin, Şafak, Akbulut, Ayhan, Yardim, Meltem, Aydin, Süleyman
Format: Article
Language:English
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Summary:Brucella spp. are facultative intracellular pathogens that can cause chronic infections in many tissues and organs. To investigate serum dermcidin, salusin-alpha, salusin-beta and TNF-alpha levels and their correlation with each other in patients with acute brucellosis. From 50 patients hospitalized upon diagnosis of acute brucellosis, blood samples were collected and dermcidin, salusin-alpha, salusin-beta and TNF-alpha levels in serum samples were measured using an ELISA assay. The control group included 40 volunteers. Brucellosis group had significantly lower plasma dermcidin, salusin- alpha, salusin-beta levels compared to the healthy control group (respectively p=0.008, p
ISSN:1735-1383
1735-367X
DOI:10.22034/iji.2019.80261