TERT-Regulation and Roles in Cancer Formation

Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase complex plays a key role in cancer formation by telomere dependent or independent mechanisms. Telomere maintenance mechanisms include complex changes such as gene amplifications, structural variants, promoter ge...

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Bibliographic Details
Published in:Frontiers in immunology 2020-11, Vol.11, p.589929-589929
Main Authors: Dratwa, Marta, Wysoczańska, Barbara, Łacina, Piotr, Kubik, Tomasz, Bogunia-Kubik, Katarzyna
Format: Article
Language:English
Subjects:
cancer progression
Immunology
telomerase reverse transcriptase
telomere maintenance mechanisms
TERT epigenetic alterations
TERT structural variants
TERTp mutations
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Summary:Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase complex plays a key role in cancer formation by telomere dependent or independent mechanisms. Telomere maintenance mechanisms include complex changes such as gene amplifications, structural variants, promoter germline and somatic mutations, epigenetic changes, and alternative lengthening of telomere. All of them are cancer specific at tissue histotype and at single cell level expression is regulated in tumors multiple genetic and epigenetic alterations which affect telomerase activity. Telomerase activity expression has an impact on telomere length and can be a useful marker in diagnosis and prognosis of various cancers and a new therapy approach. In this review we want to highlight the main roles of in different mechanisms of cancer development and regulation.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.589929