Comparative study on the hypoglycemic and antioxidative effects of fermented paste (doenjang) prepared from soybean and brown rice mixed with rice bran or red ginseng marc in mice fed with high fat diet

The effects of fermented paste made from soybean, brown rice, or brown rice in combination with rice bran or red ginseng marc on the glucose metabolism and antioxidative defense system in high fat-fed mice were investigated. The mice were given experimental diets for eight weeks: Normal control, hig...

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Bibliographic Details
Published in:Nutrients 2014-10, Vol.6 (10), p.4610-4624
Main Authors: Chung, Soo Im, Rico, Catherine W, Kang, Mi Young
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Antioxidants - administration & dosage
Antioxidants - pharmacology
antioxidative effect
Blood Glucose - drug effects
brown rice
Diet
Diet, High-Fat - adverse effects
Dietary Supplements
Erythrocytes - metabolism
Fermentation
fermented paste
Food
Glucose
Glycine max
Hyperglycemia
Hyperglycemia - diet therapy
Hyperglycemia - etiology
Hyperglycemia - metabolism
hypoglycemic effect
Lipid Peroxidation - drug effects
Male
Metabolism
Mice
Mice, Inbred C57BL
Nutrition research
Oryza
Panax
Physiology
Phytotherapy - methods
Soy Foods
soybean
Soybeans
Treatment Outcome
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Summary:The effects of fermented paste made from soybean, brown rice, or brown rice in combination with rice bran or red ginseng marc on the glucose metabolism and antioxidative defense system in high fat-fed mice were investigated. The mice were given experimental diets for eight weeks: Normal control, high fat, and high fat supplemented with soybean fermented paste, brown rice fermented paste, brown rice-rice bran fermented paste, or brown rice-red ginseng marc fermented paste. The high fat group showed markedly higher blood glucose level and erythrocyte lipid peroxidation than the normal control group. Diet supplementation of fermented paste inhibited the high fat-induced hyperglycemia and oxidative stress via regulation of the glucose-regulating and antioxidant enzymes activities. The soybean and brown rice-red ginseng marc fermented pastes were the most effective in improving the glucose metabolism and antioxidant defense status in mice under high fat diet condition. These findings illustrate that brown rice, in combination with red ginseng marc, may be useful in the development of fermented paste with strong hypoglycemic and antioxidative activities.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu6104610