Ultrasound-Responsive Biomimetic Superhydrophobic Drug-Loaded Mesoporous Silica Nanoparticles for Treating Prostate Tumor

Interfacial nanobubbles on a superhydrophobic surface can serve as ultrasound cavitation nuclei for continuously promoting sonodynamic therapy, but their poor dispersibility in blood has limited their biomedical application. In this study, we proposed ultrasound-responsive biomimetic superhydrophobi...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutics 2023-04, Vol.15 (4), p.1155
Main Authors: Jin, Qiaofeng, Chen, Dandan, Song, Yishu, Liu, Tianshu, Li, Wenqu, Chen, Yihan, Qin, Xiaojuan, Zhang, Li, Wang, Jing, Xie, Mingxing
Format: Article
Language:English
Subjects:
antivascular therapy
Biomimetics
Blood
Blood vessels
Cavitation
Chemical properties
Chemotherapy
Dosage and administration
Doxorubicin
Drug delivery systems
Drug therapy
Drug therapy, Combination
Ethanol
Health aspects
Hydrophobic surfaces
Laboratory animals
Membranes
mesoporous silica nanoparticle
Nanoparticles
Permeability
Polyethylene glycol
Prostate cancer
sonodynamic therapy
Testing
Tumors
Ultrasonic imaging
ultrasound
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Interfacial nanobubbles on a superhydrophobic surface can serve as ultrasound cavitation nuclei for continuously promoting sonodynamic therapy, but their poor dispersibility in blood has limited their biomedical application. In this study, we proposed ultrasound-responsive biomimetic superhydrophobic mesoporous silica nanoparticles, modified with red blood cell membrane and loaded with doxorubicin (DOX) (F-MSN-DOX@RBC), for RM-1 tumor sonodynamic therapy. Their mean size and zeta potentials were 232 ± 78.8 nm and -35.57 ± 0.74 mV, respectively. The F-MSN-DOX@RBC accumulation in a tumor was significantly higher than in the control group, and the spleen uptake of F-MSN-DOX@RBC was significantly reduced in comparison to that of the F-MSN-DOX group. Moreover, the cavitation caused by a single dose of F-MSN-DOX@RBC combined with multiple ultrasounds provided continuous sonodynamic therapy. The tumor inhibition rates in the experimental group were 71.5 8 ± 9.54%, which is significantly better than the control group. DHE and CD31 fluorescence staining was used to assess the reactive oxygen species (ROS) generated and the broken tumor vascular system induced by ultrasound. Finally, we can conclude that the combination of anti-vascular therapy, sonodynamic therapy by ROS, and chemotherapy promoted tumor treatment efficacy. The use of red blood cell membrane-modified superhydrophobic silica nanoparticles is a promising strategy in designing ultrasound-responsive nanoparticles to promote drug-release.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15041155