Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials in Caenorhabditis elegans

In the forms of either herbs or functional foods, plants and their products have attracted medicinal, culinary, and nutraceutical applications due to their abundance in bioactive phytochemicals. Human beings and other animals have employed those bioactive phytochemicals to improve health quality bas...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-12, Vol.26 (23), p.7323
Main Authors: Okoro, Nkwachukwu Oziamara, Odiba, Arome Solomon, Osadebe, Patience Ogoamaka, Omeje, Edwin Ogechukwu, Liao, Guiyan, Fang, Wenxia, Jin, Cheng, Wang, Bin
Format: Article
Language:English
Subjects:
Aging
Aging - drug effects
Alzheimer's disease
Animal models
Animals
Antiinfectives and antibacterials
Antioxidants
Bioactive compounds
Biological activity
By products
Caenorhabditis elegans
Caenorhabditis elegans - drug effects
Caenorhabditis elegans - physiology
Carcinogens
Functional foods & nutraceuticals
Genes
Health risks
Homeostasis
Humans
Inflammation
Kinases
Life span
lifespan
Longevity - drug effects
longevity pathways
Metabolic Networks and Pathways - drug effects
Metabolic pathways
Metabolism
Metabolites
Microorganisms
Nematodes
Neuroprotection
Organisms
Phytochemicals
Phytochemicals - pharmacology
Proteins
Review
Risk analysis
Risk factors
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Summary:In the forms of either herbs or functional foods, plants and their products have attracted medicinal, culinary, and nutraceutical applications due to their abundance in bioactive phytochemicals. Human beings and other animals have employed those bioactive phytochemicals to improve health quality based on their broad potentials as antioxidant, anti-microbial, anti-carcinogenic, anti-inflammatory, neuroprotective, and anti-aging effects, amongst others. For the past decade and half, efforts to discover bioactive phytochemicals both in pure and crude forms have been intensified using the aging model, in which various metabolic pathways in humans are highly conserved. In this review, we summarized the aging and longevity pathways that are common to and humans and collated some of the bioactive phytochemicals with health benefits and lifespan extending effects that have been studied in . This simple animal model is not only a perfect system for discovering bioactive compounds but is also a research shortcut for elucidating the amelioration mechanisms of aging risk factors and associated diseases.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26237323