M6A RNA methylation in biliary tract cancer: the function roles and potential therapeutic implications

Biliary tract cancers (BTCs) are relatively rare malignancies with a poor prognosis. For advanced BTCs, the efficacy of current chemotherapeutic approaches is limited. Consequently, there is an urgent need to deepen our understanding of the molecular mechanisms underlying BTC tumorigenesis and devel...

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Bibliographic Details
Published in:Cell death discovery 2024-02, Vol.10 (1), p.83-83, Article 83
Main Authors: Bai, Xuesong, Huang, Jianhao, Jin, Yiqun, Chen, Jiemin, Zhou, Shengnan, Dong, Liangbo, Han, Xianlin, He, Xiaodong
Format: Article
Language:English
Subjects:
631/208/176
631/67/1504/1329
Adenosine
Apoptosis
Biliary tract
Biliary tract diseases
Biochemistry
Biomarkers
Biomedical and Life Sciences
Cancer
Cell Biology
Cell Cycle Analysis
Cholangiocarcinoma
Drug resistance
Hospitals
Life Sciences
Localization
Malignancy
Medical prognosis
Medical schools
Metabolism
Methylation
Molecular modelling
N6-methyladenosine
Physiology
Proteins
Review Article
Ribonucleic acid
RNA
RNA transport
Stem Cells
Surgery
Therapeutic targets
Transfer RNA
Tumorigenesis
Tumors
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Summary:Biliary tract cancers (BTCs) are relatively rare malignancies with a poor prognosis. For advanced BTCs, the efficacy of current chemotherapeutic approaches is limited. Consequently, there is an urgent need to deepen our understanding of the molecular mechanisms underlying BTC tumorigenesis and development for the exploration of effective targeted therapies. N6-methyladenosine (m6A), the most abundant RNA modifications in eukaryotes, is found usually dysregulated and involved in tumorigenesis, progression, and drug resistance in tumors. Numerous studies have confirmed that aberrant m6A regulators function as either oncogenes or tumor suppressors in BTCs by the reversible regulation of RNA metabolism, including splicing, export, degradation and translation. In this review, we summarized the current roles of the m6A regulators and their functional impacts on RNA fate in BTCs. The improved understanding of m6A modification in BTCs also provides a reasonable outlook for the exploration of new diagnostic strategies and efficient therapeutic targets.
ISSN:2058-7716
2058-7716
DOI:10.1038/s41420-024-01849-z