Lysyl Oxidase Family Proteins: Prospective Therapeutic Targets in Cancer

The lysyl oxidase (LOX) family, consisting of LOX and LOX-like proteins 1–4 (LOXL1–4), is responsible for the covalent crosslinking of collagen and elastin, thus maintaining the stability of the extracellular matrix (ECM) and functioning in maintaining connective tissue function, embryonic developme...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-10, Vol.23 (20), p.12270
Main Authors: Wang, Wei, Wang, Xiangjun, Yao, Feng, Huang, Chao
Format: Article
Language:English
Subjects:
Apoptosis
Breast cancer
By products
cancer
Collagen
Crosslinking
Elastin
Embryogenesis
Extracellular matrix
extracellular matrix (ECM)
Gene expression
Growth factors
Hypoxia
Immunomodulation
Kinases
Liquid oxygen
LOX family
Lung cancer
Lymphatic system
Lysyl oxidase
lysyl oxidase (LOX)
Medical prognosis
Metastases
Metastasis
Peptides
Protein expression
Proteins
Review
Signal transduction
Therapeutic applications
Therapeutic targets
Tumor microenvironment
Tumors
Wound healing
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Summary:The lysyl oxidase (LOX) family, consisting of LOX and LOX-like proteins 1–4 (LOXL1–4), is responsible for the covalent crosslinking of collagen and elastin, thus maintaining the stability of the extracellular matrix (ECM) and functioning in maintaining connective tissue function, embryonic development, and wound healing. Recent studies have found the aberrant expression or activity of the LOX family occurs in various types of cancer. It has been proved that the LOX family mainly performs tumor microenvironment (TME) remodeling function and is extensively involved in tumor invasion and metastasis, immunomodulation, proliferation, apoptosis, etc. With relevant translational research in progress, the LOX family is expected to be an effective target for tumor therapy. Here, we review the research progress of the LOX family in tumor progression and therapy to provide novel insights for future exploration of relevant tumor mechanism and new therapeutic targets.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232012270