A novel SWIM domain protein ZSWIM5 inhibits the malignant progression of non-small-cell lung cancer

Zinc finger SWIM-type containing 5 (ZSWIM5) is a newly discovered protein, which contains a novel zinc-chelating domain SWIM (CxCxnCxH), and is predicted to interact with DNA or proteins. Currently, the knowledge of functions of ZSWIM5 remains limited. In this study, we aimed to elucidate the biolog...

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Bibliographic Details
Published in:Cancer management and research 2018-01, Vol.10, p.3245-3254
Main Authors: Xu, Ke, Liu, Bin, Ma, Yegang, Xu, Baojin, Xing, Xiaojing
Format: Article
Language:English
Subjects:
Cancer cells
Cancer metastasis
Care and treatment
Cell cycle
Chemotherapy
Development and progression
DNA
DNA binding proteins
Gastric cancer
Genetic aspects
Health aspects
Immunohistochemistry
Infection
invasion
Lung cancer
migration
Non-small cell lung cancer
Novels
NSCLC
Original Research
Physiological aspects
Plasmids
Polyclonal antibodies
proliferation
Proteins
Surgery
Thoracic surgery
Tumors
Wound care
Wound healing
Zinc Finger
Zinc finger proteins
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Summary:Zinc finger SWIM-type containing 5 (ZSWIM5) is a newly discovered protein, which contains a novel zinc-chelating domain SWIM (CxCxnCxH), and is predicted to interact with DNA or proteins. Currently, the knowledge of functions of ZSWIM5 remains limited. In this study, we aimed to elucidate the biological functions of ZSWIM5 and their mechanisms. We detected the expression of ZSWIM5 in samples from 139 cases of non-small-cell lung cancer (NSCLC) patients and six cell lines using immunohistochemistry and Western blot. Moreover, we explored the biological functions of ZSWIM5 in lung cancer cells by siRNA interference and cDNA transfection of ZSWIM5. The results showed that compared with adjacent non-tumor lung tissues, ZSWIM5 expression was significantly decreased in NSCLC tissues ( =0.0199) and that the ZSWIM5-positive rate in non-tumor tissues (76.67%) was notably higher than that in NSCLC tissues (40.29%). ZSWIM5 expression in human normal bronchial epithelial cells was also much higher than that in lung cancer lines (
ISSN:1179-1322
1179-1322
DOI:10.2147/CMAR.S174355