Myeloperoxidase gene-463G > A polymorphism and premature coronary artery disease

We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the gro...

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Bibliographic Details
Published in:Genetics and molecular biology 2009-01, Vol.32 (2), p.260-263
Main Authors: Zhong, Chen, Quanzhong, Yin, Genshan, Ma, Hua, Zhang, Ruolong, Zheng, Jiahong, Wang, Chunheng, Gao
Format: Article
Language:English
Subjects:
BIOCHEMISTRY & MOLECULAR BIOLOGY
GENETICS & HEREDITY
Human and Medical Genetics
myeloperoxidase
premature coronary artery disease
protective genetic polymorphism
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Summary:We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the grouping technique. We found lower frequencies of both the A/A genotype and the A allele in patients (p < 0.05). Multivariate logistic regression showed that the risk of premature CAD in subjects carrying the AA genotype was reduced by 83% in relation to individuals carrying the G/G genotype (OR = 0.172, 95% CI: 0.057-0.526, p = 0.002). Our results indicate that -463G > A polymorphism of the myeloperoxidase gene is associated with premature CAD in Chinese individuals, suggesting that the AA genotype is a protective factor against premature CAD.
ISSN:1415-4757
1678-4685
1678-4685
DOI:10.1590/S1415-47572009005000035