Applications of the Methylotrophic Yeast Komagataella phaffii in the Context of Modern Biotechnology

(formerly ) is a methylotrophic yeast widely used in laboratories around the world to produce recombinant proteins. Given its advantageous features, it has also gained much interest in the context of modern biotechnology. In this review, we present the utilization of as a platform to produce several...

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Published in:Journal of fungi (Basel) 2024-06, Vol.10 (6), p.411
Main Authors: Moraes, Lidia Maria Pepe de, Marques, Henrique Fetzner, Reis, Viviane Castelo Branco, Coelho, Cintia Marques, Leitão, Matheus de Castro, Galdino, Alexsandro Sobreira, Porto de Souza, Thais Paiva, Piva, Luiza Cesca, Perez, Ana Laura Alfonso, Trichez, Débora, de Almeida, João Ricardo Moreira, De Marco, Janice Lisboa, Torres, Fernando Araripe Gonçalves
Format: Article
Language:English
Subjects:
Amino acids
Biological products
Biomaterials
biopharmaceuticals
Biotechnology
FDA approval
Hormones
Insulin glargine
Komagataella phaffii
Ocriplasmin
Pharmaceuticals
Proteins
renewable chemicals
Review
synthetic biology
Yeast
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Summary:(formerly ) is a methylotrophic yeast widely used in laboratories around the world to produce recombinant proteins. Given its advantageous features, it has also gained much interest in the context of modern biotechnology. In this review, we present the utilization of as a platform to produce several products of economic interest such as biopharmaceuticals, renewable chemicals, fuels, biomaterials, and food/feed products. Finally, we present synthetic biology approaches currently used for strain engineering, aiming at the production of new bioproducts.
ISSN:2309-608X
2309-608X
DOI:10.3390/jof10060411