Interleukin 18 and interleukin 22 as important immune markers in patients with tuberculosis

Tuberculosis (TB) is a lung infection caused by the bacterium Mycobacterium tuberculosis (MTB). TB is a leading cause of death globally, accounting for approximately 1.5 million deaths per year. The aim of this article was to evaluate the immunological role of Interleukin (IL) 18 and Interleukin 22...

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Bibliographic Details
Published in:E3S web of conferences 2023-01, Vol.389, p.3109
Main Authors: Kamoona, Firas Mohammad Hussein, Aljanaby, Ahmed Abduljabbar Jaloob
Format: Article
Language:English
Subjects:
genexpert
il18
il22
mdrmtb
mtb
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Summary:Tuberculosis (TB) is a lung infection caused by the bacterium Mycobacterium tuberculosis (MTB). TB is a leading cause of death globally, accounting for approximately 1.5 million deaths per year. The aim of this article was to evaluate the immunological role of Interleukin (IL) 18 and Interleukin 22 in patients infected with MTB and multi-drug resistant tuberculosis MDRTB. A total of 182 individuals suspected with MTB admitted to the tuberculosis center in AL-Najaf City, Iraq. A sputum acid-fast stain was performed for each individual and GeneXpert® heminested real time PCR has been performed for MDRTB detection. The two Interleukins was measurement in serum of infected individual using ELISA technique. Out of 182 individuals, there were 20 infected with MTB and 15 infected with MDRTB. Serum IL18 and IL22 levels were significantly elevated (P
ISSN:2267-1242
2267-1242
DOI:10.1051/e3sconf/202338903109