Graft-versus-host disease in a child with neuroblastoma after autologous stem cell transplantation

In the pediatric population, hematopoietic stem cell transplantation (HSCT) is used to treat a wide variety of diseases, both malignant and nonmalignant. For many of these diseases, HSCT is a well-established treatment. Acute graft-versus-host disease (GVHD) continues to be a leading cause of morbid...

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Bibliographic Details
Published in:Contemporary oncology (Poznań, Poland) Poland), 2019-01, Vol.23 (1), p.59-62
Main Authors: Yaman, Yöntem, Baysoy, Gökhan, Keleşoğlu, Emre, Özdilli, Kürşat, Çakır, Aslı, Dildar Bahar Genç, Elli, Murat, Anak, Sema
Format: Article
Language:English
Subjects:
autologous stem cell transplantation
Biopsy
Bone marrow
Case Report
Chemotherapy
child
Colonoscopy
Cytomegalovirus
Diarrhea
Disease
Drug dosages
graft-versus-host disease
Hematology
Immunoglobulins
Metastasis
Multiple myeloma
Neuroblastoma
Oncology
Patients
Pediatrics
Stem cells
Transplants & implants
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Summary:In the pediatric population, hematopoietic stem cell transplantation (HSCT) is used to treat a wide variety of diseases, both malignant and nonmalignant. For many of these diseases, HSCT is a well-established treatment. Acute graft-versus-host disease (GVHD) continues to be a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Graft versus host disease is a common complication of allo-SCT which is induced by donor T cell recognition of recipient alloantigens. The occurrence of autologous GVHD suggests that inappropriate recognition of host self-antigens may occur. GVHD in patients who received autologous HSCT is extremely rare compared to patients who received allogeneic HSCT. We present the case of a 4-year-old girl with metastatic neuroblastoma who spontaneously developed autologous GVHD after autologous HSCT.
ISSN:1428-2526
1897-4309
DOI:10.5114/wo.2019.83815