The Structure and Nephroprotective Activity of Oligo-Porphyran on Glycerol-Induced Acute Renal Failure in Rats

Porphyran is a sulfate galactan in the cell wall of . Its acid hydrolysis product, oligo-porphyran (OP), was prepared and the structure studied by electrospray ionization time-of-flight mass spectrometry (ESI-TOF-MS). This oligosaccharide was mainly composed of monosulfate-oligo-galactan, disufate-o...

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Bibliographic Details
Published in:Marine drugs 2017-05, Vol.15 (5), p.135
Main Authors: Wang, Jing, Hou, Yun, Duan, Delin, Zhang, Quanbin
Format: Article
Language:English
Subjects:
Acute Kidney Injury - blood
Acute Kidney Injury - chemically induced
Acute Kidney Injury - drug therapy
acute renal failure
Animals
Blood
Blood Urea Nitrogen
Casts
Cell walls
Collecting duct
Creatinine
Creatinine - blood
Degree of polymerization
Dilation
Female
Functional anatomy
gender difference
Glycerol
Glycerol - pharmacology
Hydrolysis
Ionization
Ions
Ions - blood
Ions - urine
Kidney - drug effects
Kidneys
Male
Mass spectrometry
Mass spectroscopy
Mortality
Nitrogen
oligo-porphyran
Oligosaccharides - pharmacology
Polymerization
Porphyra
Protection
Protective Agents - pharmacology
Rats
Rats, Sprague-Dawley
Renal failure
Sepharose - analogs & derivatives
Sepharose - pharmacology
Serum
sulfated galactan
Urea
Urine
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Summary:Porphyran is a sulfate galactan in the cell wall of . Its acid hydrolysis product, oligo-porphyran (OP), was prepared and the structure studied by electrospray ionization time-of-flight mass spectrometry (ESI-TOF-MS). This oligosaccharide was mainly composed of monosulfate-oligo-galactan, disufate-oligo-galactan, trisulfate-oligo-galactan, trisulfate oligo-methyl-galactan, and 3,6-anhydrogalactose with the degree of polymerization ranging from 1 to 8. The effects of OP were investigated in the glycerol-induced acute renal failure (ARF) model. Compared with the normal group, rats from the glycerol-induced group exhibited collecting duct and medullary ascending limb dilation and casts. The OP-treated group exerted a protective effect against glycerol-induced changes. The results showed that the administration of OP markedly decreased mortality in female ARF rats. For male ARF rats, all of which survived, OP significantly decreased the blood urea nitrogen and serum creatinine levels. Ion levels in plasma and urine were significantly changed in ARF rats, whereas OP treatment almost recovered ion levels back to normal. This study showed a noticeable renal morphologic and functional protection by OP in glycerol-induced ARF rats.
ISSN:1660-3397
1660-3397
DOI:10.3390/md15050135