Comparative Genomics of the Aeromonadaceae Core Oligosaccharide Biosynthetic Regions

Lipopolysaccharides (LPSs) are an integral part of the Gram-negative outer membrane, playing important organizational and structural roles and taking part in the bacterial infection process. In , , and , three different genomic regions taking part in the LPS core oligosaccharide (Core-OS) assembly h...

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Bibliographic Details
Published in:International journal of molecular sciences 2017-02, Vol.18 (3), p.519-519
Main Authors: Forn-Cuní, Gabriel, Merino, Susana, Tomás, Juan M
Format: Article
Language:English
Subjects:
Aeromonadaceae - genetics
Aeromonadaceae - metabolism
Aeromonas
Aeromonas hydrophila
Bacterial genetics
Bacteris patògens
Gene Order
Genes, Bacterial
Genome, Bacterial
genomics
Genomics - methods
Genètica bacteriana
inner core oligosaccharide
lipopolysaccharide
Lipopolysaccharides - biosynthesis
Lipopolysaccharides - chemistry
Oligosaccharides - biosynthesis
Oligosaccharides - chemistry
outer core oligosaccharide
Pathogenic bacteria
Piscicola
Salmonidae
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Summary:Lipopolysaccharides (LPSs) are an integral part of the Gram-negative outer membrane, playing important organizational and structural roles and taking part in the bacterial infection process. In , , and , three different genomic regions taking part in the LPS core oligosaccharide (Core-OS) assembly have been identified, although the characterization of these clusters in most aeromonad species is still lacking. Here, we analyse the conservation of these LPS biosynthesis gene clusters in the all the 170 currently public genomes, including 30 different species, and characterise the structure of a putative common inner Core-OS in the family. We describe three new genomic organizations for the inner Core-OS genomic regions, which were more evolutionary conserved than the outer Core-OS regions, which presented remarkable variability. We report how the degree of conservation of the genes from the inner and outer Core-OS may be indicative of the taxonomic relationship between species.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms18030519