Comparison of Midazolam and Propofol for BIS-Guided Sedation During Regional Anaesthesia

Regional anaesthesia has become an important anaesthetic technique. Effective sedation is an essential for regional techniques too. This study compares midazolam and propofol in terms of onset & recovery from sedation, dosage and side effects of both the drugs using Bispectral Index monitoring....

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Bibliographic Details
Published in:Indian journal of anaesthesia 2009-11, Vol.53 (6), p.662-666
Main Authors: Khurana, Priyanka, Agarwal, Ankit, Verma, Rk, Gupta, Pk
Format: Article
Language:English
Subjects:
Anesthesia
Blood pressure
Clinical Investigation
Health aspects
Heart rate
Midazolam
Propofol
Regional anesthesia
Sedation
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Summary:Regional anaesthesia has become an important anaesthetic technique. Effective sedation is an essential for regional techniques too. This study compares midazolam and propofol in terms of onset & recovery from sedation, dosage and side effects of both the drugs using Bispectral Index monitoring. Ninety eight patients were randomly divided into two groups,one group recieved midazolam infusion while the other recieved propofol infusion until BIS reached 75. We observed Time to reach desired sedation, HR, MABP, time for recovery, dose to reach sedation and for maintenance of sedation and side effects if any. The time to reach required sedation was 11 min in Midazolam group(Group I) while it was 6 min in Propofol group(Group II) (p=0.0). Fall in MABP was greater with propofol. Recovery in with midazolam was slower than with propofol (18.6 +/- 6.5 vs 10.10+/-3.65 min) (p=0.00). We concluded that both midazolam and propofol are effective sedatives, but onset and offset was quicker with propofol, while midazolam was more cardiostable.
ISSN:0019-5049
0976-2817