Bottom-up assembly of viral replication cycles

Bottom-up synthetic biology provides new means to understand living matter by constructing minimal life-like systems. This principle can also be applied to study infectious diseases. Here we summarize approaches and ethical considerations for the bottom-up assembly of viral replication cycles. Synth...

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Bibliographic Details
Published in:Nature communications 2022-11, Vol.13 (1), p.6530-6530, Article 6530
Main Authors: Staufer, Oskar, Gantner, Gösta, Platzman, Ilia, Tanner, Klaus, Berger, Imre, Spatz, Joachim P.
Format: Article
Language:English
Subjects:
631/1647/2204
631/326/596/4130
Assembly
Biology
Design
Genetic engineering
Glycoproteins
Humanities and Social Sciences
Infections
Infectious diseases
multidisciplinary
Perspective
Principles
Propagation
Redesign
Replication
Science
Science (multidisciplinary)
Severe acute respiratory syndrome coronavirus 2
Synthetic Biology
Viral infections
Virus Replication
Viruses
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Summary:Bottom-up synthetic biology provides new means to understand living matter by constructing minimal life-like systems. This principle can also be applied to study infectious diseases. Here we summarize approaches and ethical considerations for the bottom-up assembly of viral replication cycles. Synthetic biology encompasses engineering approaches to either redesign biological organisms with new molecular abilities or build up organism from the bottom to improve our understanding of life. Here, the authors summarize current approaches that can be applied for the synthetic engineering of viral replication cycles and discuss the potential DURC risk associated with such bottom-up approaches in infectious disease.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-022-33661-7