Neurological Applications of Celery ( Apium graveolens ): A Scoping Review

is an indigenous plant in the family Apiaceae, or Umbelliferae, that contains many active compounds. It has been used traditionally to treat arthritic conditions, gout, and urinary infections. The authors conducted a scoping review to assess the quality of available evidence on the overall effects o...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-08, Vol.28 (15), p.5824
Main Authors: Tan, Terence Yew Chin, Lim, Xin Yi, Norahmad, Nor Azrina, Chanthira Kumar, Hemahwathy, Teh, Bee Ping, Lai, Nai Ming, Syed Mohamed, Ami Fazlin
Format: Article
Language:English
Subjects:
3-n-butylphthalide
Alzheimer's disease
Apium graveolens
Apoptosis
celery
central nervous system
Dengue fever
Diabetes
Health aspects
Medical research
Medicine, Experimental
NBP
Nervous system diseases
Neurological disorders
Neurotoxicity
Oxidative stress
Parkinson's disease
Phytochemicals
Review
Tranquilizers
Tumor necrosis factor-TNF
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Summary:is an indigenous plant in the family Apiaceae, or Umbelliferae, that contains many active compounds. It has been used traditionally to treat arthritic conditions, gout, and urinary infections. The authors conducted a scoping review to assess the quality of available evidence on the overall effects of celery when treating neurological disorders. A systematic search was performed using predetermined keywords in selected electronic databases. The 26 articles included upon screening consisted of 19 in vivo studies, 1 published clinical trial, 4 in vitro studies and 2 studies comprising both in vivo and in vitro methods. and its bioactive phytoconstituent, 3-n-butylphthalide (NBP), have demonstrated their effect on neurological disorders such as Alzheimer's disease, Parkinson's disease, stroke-related neurological complications, depression, diabetes-related neurological complications, and epilepsy. The safety findings were minimal, showing that NBP is safe for up to 18 weeks at 15 mg/kg in animal studies, while there were adverse effects (7%) reported when consuming NBP for 24 weeks at 600 mg daily in human trials. In conclusion, the safety of extract and NBP can be further investigated clinically on different neurological disorders based on their potential role in different targeted pathways.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28155824