Pharmacokinetics and drug delivery systems for puerarin, a bioactive flavone from traditional Chinese medicine

Pueraria lobata (Willd.) Ohwi is a medicinal and edible homologous plant with a long history in China. Puerarin, the main component isolated from the root of Pueraria lobata, possesses a wide range of pharmacological properties. Daidzein and glucuronides are the main metabolites of puerarin and are...

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Bibliographic Details
Published in:Drug delivery 2019-01, Vol.26 (1), p.860-869
Main Author: Zhang, Liang
Format: Article
Language:English
Subjects:
Animals
Bioavailability
Biological Availability
Breeding of animals
Chinese medicine
dendrimers
Diabetes
Disease
Drug delivery systems
Drug Delivery Systems - methods
Drug dosages
Flavones - administration & dosage
Flavones - pharmacokinetics
Humans
Isoflavones - administration & dosage
Isoflavones - pharmacokinetics
Liver
Medicine, Chinese Traditional - methods
Metabolism
Metabolites
Microemulsions
Nanocrystals
Nanoparticles
Pharmaceutical sciences
Pharmacokinetics
poorly soluble drug
Puerarin
Review
Solubility - drug effects
Urine
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Summary:Pueraria lobata (Willd.) Ohwi is a medicinal and edible homologous plant with a long history in China. Puerarin, the main component isolated from the root of Pueraria lobata, possesses a wide range of pharmacological properties. Daidzein and glucuronides are the main metabolites of puerarin and are excreted in the urine and feces. As active substrates of P-gp, multidrug resistance-associated protein and multiple metabolic enzymes, the pharmacokinetics of puerarin can be influenced by different pathological conditions and drug-drug interactions. Due to the poor water-solubility and liposolubility, the applications of puerarin are limited. So far, only puerarin injections and eye drops are on the market. Recent years, researches on improving the bioavailability of puerarin are developing rapidly, various nanotechnologies and preparation technologies including microemulsions and SMEDDS, dendrimers, nanoparticles and nanocrystals have been researched to improve the bioavailability of puerarin. In order to achieve biocompatibility and desired activity, more effective quality evaluations of nanocarriers are required. In this review, we summarize the pharmacokinetics and drug delivery systems of puerarin up to date.
ISSN:1071-7544
1521-0464
DOI:10.1080/10717544.2019.1660732