Effect of dietary fiber and threonine content on intestinal barrier function in pigs challenged with either systemic E. coli lipopolysaccharide or enteric Salmonella Typhimurium

The independent and interactive effects of dietary fiber (DF) and threonine (Thr) were investigated in growing pigs challenged with either systemic lipopolysaccharide (LPS) or enteric Typhimurium (ST) to characterise their effect on intestinal barrier function. In experiment 1, intestinal barrier fu...

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Bibliographic Details
Published in:Journal of animal science and biotechnology 2020-04, Vol.11 (1), p.38-38, Article 38
Main Authors: Wellington, Michael O, Hamonic, Kimberley, Krone, Jack E C, Htoo, John K, Van Kessel, Andrew G, Columbus, Daniel A
Format: Article
Language:English
Subjects:
Barrier function
biotechnology
Cecum
Chromatography
Colon
Diet
Dietary fiber
digesta
E coli
E. coli lipopolysaccharide
Escherichia coli
Experiments
Fatty acids
Feces
Fiber
Gene expression
Glycoproteins
Goblet cells
Hogs
ileum
Inoculation
Intestine
Lactulose
Lipopolysaccharides
Mannitol
Morphology
MUC2 gene
Mucin
mucins
Salmonella
Salmonella Typhimurium
secretion
Small intestine
Swine
Threonine
Urine
volatile fatty acids
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Summary:The independent and interactive effects of dietary fiber (DF) and threonine (Thr) were investigated in growing pigs challenged with either systemic lipopolysaccharide (LPS) or enteric Typhimurium (ST) to characterise their effect on intestinal barrier function. In experiment 1, intestinal barrier function was assessed via oral lactulose and mannitol (L:M) gavage and fecal mucin analysis in pigs challenged with LPS and fed low fiber (LF) or high fiber (HF) diets with graded dietary Thr. Urinary lactulose recovery and L:M ratio increased (  
ISSN:1674-9782
2049-1891
2049-1891
DOI:10.1186/s40104-020-00444-3