Neuroprotective Activity of Water Soluble Extract from Chorispora bungeana against Focal Cerebral Ischemic/Reperfusion Injury in Mice

The purpose of the present study was to clarify whether the water extract of Chorispora bungeana was an antioxidant agent against cerebral ischemia/reperfusion (I/R). Our results showed that water extract of Chorispora bungeana treatment significantly reduced neurological deficit scores, infarct siz...

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Bibliographic Details
Published in:Journal of chemistry 2014-01, Vol.2014 (2014), p.1-9
Main Authors: An, Li-Zhe, Li, Yu-Yao, Li, Ya-Bo, Dai, Xue-Ling, Liu, Ting, Sun, Ya-Xuan, Zhang, Hua
Format: Article
Language:English
Subjects:
Cerebral ischemia
Cruciferae
Health aspects
Materia medica, Vegetable
Plant extracts
Prevention
Reperfusion injury
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Summary:The purpose of the present study was to clarify whether the water extract of Chorispora bungeana was an antioxidant agent against cerebral ischemia/reperfusion (I/R). Our results showed that water extract of Chorispora bungeana treatment significantly reduced neurological deficit scores, infarct size, MDA and carbonyl contents, and GSH/GSSG ratio compared with the model control group. After being treated by Chorispora bungeana, SOD, CAT, and GSH-Px activities remarkably increased. Chorispora bungeana treatment also improved 8-OHdG expression and cell apoptosis. Our findings indicated that the water extract of Chorispora bungeana possesses neuroprotective effect which is most likely achieved by antioxidant and antiapoptotic activities.
ISSN:2090-9063
2090-9071
DOI:10.1155/2014/373872