Significance of Atrial and Brain Natriuretic Peptide Measurements in Fetuses With Heart Failure

Fetal heart failure is mainly caused by congenital heart defect and arrhythmia. It is difficult to appropriately diagnose the severity of fetal heart failure simply by ultrasonography because the development of a fetal heart in fetoplacental circulation and how well the fetal myocardium can adapt to...

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Bibliographic Details
Published in:Frontiers in physiology 2021-03, Vol.12, p.654356-654356
Main Authors: Miyoshi, Takekazu, Hosoda, Hiroshi, Minamino, Naoto
Format: Article
Language:English
Subjects:
arrhythmia
congenital heart defect
fetal heart failure
metabolism
natriuretic peptide
Physiology
placenta
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Summary:Fetal heart failure is mainly caused by congenital heart defect and arrhythmia. It is difficult to appropriately diagnose the severity of fetal heart failure simply by ultrasonography because the development of a fetal heart in fetoplacental circulation and how well the fetal myocardium can adapt to postnatal cardiopulmonary circulation are challenging to assess. In adult cardiology, natriuretic peptides (NPs) are the most useful biomarker of heart failure; however, studies investigating NP levels in the fetuses and amniotic fluid are quite limited. Furthermore, little is known about their production and metabolism. This review summarized the most relevant findings on NP levels in the umbilical cord blood and amniotic fluid. The findings can then extend their use as a diagnostic biomarker of heart failure in fetuses with congenital heart defect and/or arrhythmia.
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2021.654356