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Therapeutic effects of anodal transcranial direct current stimulation in a rat model of ADHD
Most therapeutic candidates for treating attention-deficit hyperactivity disorder (ADHD) have focused on modulating the dopaminergic neurotransmission system with neurotrophic factors. Regulation of this system by transcranial direct current stimulation (tDCS) could contribute to the recovery of cog...
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| Published in: | eLife 2020-09, Vol.9 |
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| creator | Jung, Da Hee Ahn, Sung Min Pak, Malk Eun Lee, Hong Ju Jung, Young Jin Kim, Ki Bong Shin, Yong-Il Shin, Hwa Kyoung Choi, Byung Tae |
| description | Most therapeutic candidates for treating attention-deficit hyperactivity disorder (ADHD) have focused on modulating the dopaminergic neurotransmission system with neurotrophic factors. Regulation of this system by transcranial direct current stimulation (tDCS) could contribute to the recovery of cognitive symptoms observed in patients with ADHD. Here, male spontaneously hypertensive rats (SHR) were subjected to consecutive high-definition tDCS (HD-tDCS) (20 min, 50 μA, current density 63.7 A/m
, charge density 76.4 kC/m
) over the prefrontal cortex. This treatment alleviated cognitive deficits, with an increase in tyrosine hydroxylase and vesicular monoamine transporter two and significantly decreased plasma membrane reuptake transporter (DAT). HD-tDCS application increased the expression of several neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF), and activated hippocampal neurogenesis. Our results suggest that anodal HD-tDCS over the prefrontal cortex may ameliorate cognitive dysfunction via regulation of DAT and BDNF in the mesocorticolimbic dopaminergic pathways, and therefore represents a potential adjuvant therapy for ADHD. |
| doi_str_mv | 10.7554/ELIFE.56359 |
| format | article |
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, charge density 76.4 kC/m
) over the prefrontal cortex. This treatment alleviated cognitive deficits, with an increase in tyrosine hydroxylase and vesicular monoamine transporter two and significantly decreased plasma membrane reuptake transporter (DAT). HD-tDCS application increased the expression of several neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF), and activated hippocampal neurogenesis. Our results suggest that anodal HD-tDCS over the prefrontal cortex may ameliorate cognitive dysfunction via regulation of DAT and BDNF in the mesocorticolimbic dopaminergic pathways, and therefore represents a potential adjuvant therapy for ADHD.</description><identifier>ISSN: 2050-084X</identifier><identifier>EISSN: 2050-084X</identifier><identifier>DOI: 10.7554/ELIFE.56359</identifier><identifier>PMID: 32955434</identifier><language>eng</language><publisher>England: eLife Science Publications, Ltd</publisher><subject>Animals ; anodal transcranial direct current stimulation ; Attention Deficit Disorder with Hyperactivity - metabolism ; Attention deficit hyperactivity disorder ; brain-derived neurotrophic factor ; Disease Models, Animal ; dopaminergic neurotransmission factor ; High definition television ; Hypertension ; Male ; Nerve Growth Factors - metabolism ; Neuroscience ; Plasma Membrane Neurotransmitter Transport Proteins - metabolism ; Prefrontal Cortex - chemistry ; Prefrontal Cortex - metabolism ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Transcranial Direct Current Stimulation ; Tyrosine</subject><ispartof>eLife, 2020-09, Vol.9</ispartof><rights>2020, Jung et al.</rights><rights>COPYRIGHT 2020 eLife Science Publications, Ltd.</rights><rights>2020, Jung et al 2020 Jung et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c590t-588f2e1caa6f6b445923daefee204322d9165dbd1a06dcb1bcdd1dfb50685f093</citedby><cites>FETCH-LOGICAL-c590t-588f2e1caa6f6b445923daefee204322d9165dbd1a06dcb1bcdd1dfb50685f093</cites><orcidid>0000-0001-5724-4653 ; 0000-0002-5965-4346</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535928/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535928/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,37013,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32955434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jung, Da Hee</creatorcontrib><creatorcontrib>Ahn, Sung Min</creatorcontrib><creatorcontrib>Pak, Malk Eun</creatorcontrib><creatorcontrib>Lee, Hong Ju</creatorcontrib><creatorcontrib>Jung, Young Jin</creatorcontrib><creatorcontrib>Kim, Ki Bong</creatorcontrib><creatorcontrib>Shin, Yong-Il</creatorcontrib><creatorcontrib>Shin, Hwa Kyoung</creatorcontrib><creatorcontrib>Choi, Byung Tae</creatorcontrib><title>Therapeutic effects of anodal transcranial direct current stimulation in a rat model of ADHD</title><title>eLife</title><addtitle>Elife</addtitle><description>Most therapeutic candidates for treating attention-deficit hyperactivity disorder (ADHD) have focused on modulating the dopaminergic neurotransmission system with neurotrophic factors. Regulation of this system by transcranial direct current stimulation (tDCS) could contribute to the recovery of cognitive symptoms observed in patients with ADHD. Here, male spontaneously hypertensive rats (SHR) were subjected to consecutive high-definition tDCS (HD-tDCS) (20 min, 50 μA, current density 63.7 A/m
, charge density 76.4 kC/m
) over the prefrontal cortex. This treatment alleviated cognitive deficits, with an increase in tyrosine hydroxylase and vesicular monoamine transporter two and significantly decreased plasma membrane reuptake transporter (DAT). HD-tDCS application increased the expression of several neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF), and activated hippocampal neurogenesis. Our results suggest that anodal HD-tDCS over the prefrontal cortex may ameliorate cognitive dysfunction via regulation of DAT and BDNF in the mesocorticolimbic dopaminergic pathways, and therefore represents a potential adjuvant therapy for ADHD.</description><subject>Animals</subject><subject>anodal transcranial direct current stimulation</subject><subject>Attention Deficit Disorder with Hyperactivity - metabolism</subject><subject>Attention deficit hyperactivity disorder</subject><subject>brain-derived neurotrophic factor</subject><subject>Disease Models, Animal</subject><subject>dopaminergic neurotransmission factor</subject><subject>High definition television</subject><subject>Hypertension</subject><subject>Male</subject><subject>Nerve Growth Factors - metabolism</subject><subject>Neuroscience</subject><subject>Plasma Membrane Neurotransmitter Transport Proteins - metabolism</subject><subject>Prefrontal Cortex - chemistry</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Inbred WKY</subject><subject>Transcranial Direct Current Stimulation</subject><subject>Tyrosine</subject><issn>2050-084X</issn><issn>2050-084X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptkttrFDEUxgdRbKl98l0GfFHKrrnO5UVY2q1dWBC0gg9COJOcbFNmJtskI_rfN9utpQsmkNv5fR85ySmKt5TMaynFp-V6dbmcy4rL9kVxzIgkM9KIny-frY-K0xhvSW61aBravi6OOGuzmIvj4tf1DQbY4pScLtFa1CmW3pYwegN9mQKMUefB5Y1xIYdLPYWAYypjcsPUQ3J-LN1YQhkglYM32O8MFhdXF2-KVxb6iKeP80nx43J5fX41W3_9sjpfrGdatiTNZNNYhlQDVLbqhJAt4wbQIjIiOGOmpZU0naFAKqM72mljqLGdJFUjLWn5SbHa-xoPt2ob3ADhr_Lg1MOBDxsFISfYo8IswoZ3XAgjRI3AOso0q6zptBBAstfnvdd26gY0OmcaoD8wPYyM7kZt_G9Vy_wHrMkGHx4Ngr-bMCY1uKix72FEP0XFhBAVaWRdZ_T9Ht1Avpobrc-OeoerRcVr0baU76j5f6jcDQ5O-xGty-cHgo8Hgswk_JM2MMWoVt-_HbJne1YHH2NA-5QpJWpXYQrXzqJ6qLBMv3v-OE_sv3ri9_wty3o</recordid><startdate>20200921</startdate><enddate>20200921</enddate><creator>Jung, Da Hee</creator><creator>Ahn, Sung Min</creator><creator>Pak, Malk Eun</creator><creator>Lee, Hong Ju</creator><creator>Jung, Young Jin</creator><creator>Kim, Ki Bong</creator><creator>Shin, Yong-Il</creator><creator>Shin, Hwa Kyoung</creator><creator>Choi, Byung Tae</creator><general>eLife Science Publications, Ltd</general><general>eLife Sciences Publications, Ltd</general><general>eLife Sciences Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5724-4653</orcidid><orcidid>https://orcid.org/0000-0002-5965-4346</orcidid></search><sort><creationdate>20200921</creationdate><title>Therapeutic effects of anodal transcranial direct current stimulation in a rat model of ADHD</title><author>Jung, Da Hee ; 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, charge density 76.4 kC/m
) over the prefrontal cortex. This treatment alleviated cognitive deficits, with an increase in tyrosine hydroxylase and vesicular monoamine transporter two and significantly decreased plasma membrane reuptake transporter (DAT). HD-tDCS application increased the expression of several neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF), and activated hippocampal neurogenesis. Our results suggest that anodal HD-tDCS over the prefrontal cortex may ameliorate cognitive dysfunction via regulation of DAT and BDNF in the mesocorticolimbic dopaminergic pathways, and therefore represents a potential adjuvant therapy for ADHD.</abstract><cop>England</cop><pub>eLife Science Publications, Ltd</pub><pmid>32955434</pmid><doi>10.7554/ELIFE.56359</doi><orcidid>https://orcid.org/0000-0001-5724-4653</orcidid><orcidid>https://orcid.org/0000-0002-5965-4346</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals anodal transcranial direct current stimulation Attention Deficit Disorder with Hyperactivity - metabolism Attention deficit hyperactivity disorder brain-derived neurotrophic factor Disease Models, Animal dopaminergic neurotransmission factor High definition television Hypertension Male Nerve Growth Factors - metabolism Neuroscience Plasma Membrane Neurotransmitter Transport Proteins - metabolism Prefrontal Cortex - chemistry Prefrontal Cortex - metabolism Rats Rats, Inbred SHR Rats, Inbred WKY Transcranial Direct Current Stimulation Tyrosine |
| title | Therapeutic effects of anodal transcranial direct current stimulation in a rat model of ADHD |
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